网页Synthesis of anilines ortho-andpara-substituted aryl halides can give rise to only 2- and 3-substituted arynes, respectively, meta-substituted aryl halides can give rise to either or both isomers. The direction of elimination for a meta-substituted halide is …
Aniline synthesis by amination (arylation) - Organic Chemistry …
网页A metal-free synthesis of primary aromatic amines from arylboronic acids affords structurally diverse primary arylamines in good chemical yields, including various halogenated primary anilines. The reaction is operationally simple, requires only a slight excess of aminating agent, proceeds under neutral or …
Synthesis of meta -carbonyl phenols and anilines - Nature
网页2024年3月18日 · Compared to phenols, the synthesis of anilines from a corresponding C (sp 2)–H bond involves multistep sequences and/or harsh conditions. For instance, it was first converted into nitro, nitroso,...
Synthesis of Anilines - Hartwig - Wiley Online Library
网页A research group from Bayer screened 80 ligands for the monoarylation of aniline with the activated aryl chloride para-chloronitrobenzene. Aniline was used as a neat reagent, CuBr and CuBr 2 were found to be the most effective copper sources and …
From alkylarenes to anilines via site-directed carbon–carbon ... - Nature
网页2018年10月29日 · Here we report a previously elusive C–C amination protocol for aniline synthesis from simple and readily available alkylarenes or substituted benzyl alcohols to achieve a site-directed aniline...
A photochemical dehydrogenative strategy for aniline synthesis
网页2020年8月5日 · Condensation between amines and carbonyls, a process that frequently occurs in nature and is often used by (bio-)organic chemists 7, enables a predetermined and site-selective carbon–nitrogen...
Direct and Practical Synthesis of Primary Anilines through Iron ...
网页2016年10月31日 · The direct C–H amination of arenes is an important strategy to streamline the discovery and preparation of functional molecules. Herein, we report an operationally simple arene C–H amination reaction that, in contrast to most literature precedent, affords directly the synthetically versatile primary …
Aniline - Wikipedia
网页It is an industrially significant commodity chemical, as well as a versatile starting material for fine chemical synthesis. Its main use is in the manufacture of precursors to polyurethane, dyes, and other industrial chemicals. Like most volatile amines, it has the odor of rotten fish.
Toward High Selectivity Aniline Synthesis Catalysis at Elevated ...
网页2021年12月1日 · Two Pd/Al 2 O 3 catalysts (GU-1 and GU-2) have been examined for their suitability as aniline synthesis catalysts for application in a unit operation with suitable heat recovery capability. Nitrobenzene hydrogenation in the vapor phase has been investigated in a microreactor arrangement in the presence of a large hydrogen excess.
Formal Aniline Synthesis from Phenols through Deoxygenative N …
网页2019年9月19日 · Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source.
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