BST1 - Wikipedia
网页Bst1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis.
CD38 and CD157: A long journey from activation markers to ...
网页2013年8月2日 · This review summarizes the findings obtained from different approaches, which led to CD38 being re-defined as a multifunctional molecule. CD38 and its homologue CD157 (BST-1), contiguous gene duplicates on human chromosome 4 (4p15), are part of a gene family encoding products that modulate the …
Genetic polymorphisms of bone marrow stromal cell antigen-1 (BST-1 …
网页2023年5月29日 · BST-1/CD157, along with its paralogue CD38, constitutes a nicotinamide adenine dinucleotidase (NADase)/ADP-ribosyl cyclase family (2–10). These two enzymes catalyze the synthesis of cyclic ADP-ribose (cADPR) from NAD + and thereby regulate the intracellular Ca 2+ homeostasis (8–10).
The Pharmacology of CD38/NADase: An emerging target for …
网页Does BST-1, a protein homologous to CD38, play a role in organismal NAD homeostasis? Will NAD-boosting therapies be an effective way to treat or prevent age-related diseases and metabolic syndrome? Does the combination of CD38 inhibitors with NAD precursors present an advantage in NAD boosting therapy for age-related diseases?
Structure and Enzymatic Functions of Human CD38 - PMC
网页2006年10月8日 · CD38 is a novel multifunctional protein that serves not only as an antigen but also as an enzyme. It catalyzes the metabolism of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate, two structurally and functionally distinct Ca 2+ messengers targeting, respectively, the endoplasmic reticulum and lysosomal Ca 2+ stores. The ...
网页Of particular interest was the identification of a CD38-related gene, called BST-1 in the human (18) and BP3 in the mouse (19), that also maps to human chromosome 4 (4p15; T. Hirano, personal communication) and to mouse chromosome 5 (C. Dong, personal communication), re-spectively.
BST-1, a surface molecule of bone marrow stromal cell lines that ...
网页1994年6月7日 · The deduced amino acid sequence of BST-1 exhibited 33% identity with CD38. BST-1 was expressed in a wide range of tissues and in umbilical vein endothelial cells, whereas it was scarcely expressed in a variety of hematopoietic cell lines. The gene for BST-1 was assigned to chromosome 14q32.3, where …
Structure and Enzymatic Functions of Human CD38
网页2006年12月7日 · CD38 is a novel multifunctional protein that serves not only as an antigen but also as an enzyme. It catalyzes the metabolism of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate, two structurally and functionally distinct Ca2+ messengers targeting, respectively, the endoplasmic reticulum and lysosomal Ca2+ stores.
History and Perspectives of Research in Bone Marrow Stromal …
网页2014年12月1日 · cADP-ribose, which is produced by ecto-ADP-ribosyl cyclase of CD38 or bone marrow stromal cell antigen-1 (BST-1), is a key regulator of Ca2+-induced calcium release in an...
BST1 regulates nicotinamide riboside metabolism via its
网页2021年11月19日 · BST1 is a paralog of CD38 and its contiguous gene duplicates on human chromosome 4 or murine chromosome 5 54,55,56. CD38 reportedly has both NAD + glycohydrolase and ADP-ribosyl cyclase...