CCL5/CCR5 axis in human diseases and related treatments
网页2021年8月26日 · This review focuses on how CCL5/CCR5 axis participates in the pathological processes of different diseases and their relevant signaling pathways for the regulation of the axis. Moreover, we highlighted the gene therapy and chemotherapy studies for treating CCR5-related diseases, including the ongoing clinical trials.
The CCL5/CCR5 Axis in Cancer Progression - PubMed
网页2020年7月2日 · Numerous preclinical in vitro and in vivo studies have shown a key role of the CCL5/CCR5 axis in cancer, and thus provided the rationale for clinical trials using the repurposed drug maraviroc, a CCR5 antagonist used to treat HIV/AIDS. This review summarizes current knowledge on the role of the CCL5/CCR5 axis in cancer.
The CCL5/CCR5 Axis in Cancer Progression - PMC - National …
网页2020年7月2日 · Numerous preclinical in vitro and in vivo studies have shown a key role of the CCL5/CCR5 axis in cancer, and thus provided the rationale for clinical trials using the repurposed drug maraviroc, a CCR5 antagonist used to treat HIV/AIDS. This review summarizes current knowledge on the role of the CCL5/CCR5 axis in cancer.
Macrophage-derived CCL5 facilitates immune escape of
网页2019年12月4日 · C-C motif chemokine ligand 5 (CCL5), which is secreted by macrophages, inhibited T-cell-mediated killing of HT29 cells and promoted immune escape by stabilizing PD-L1 in...
CCL5 promotion of bioenergy metabolism is crucial for …
网页2021年4月30日 · CCL5 promotes aerobic glucose metabolism, mitochondrial ATP generation and purine synthesis, improving synaptic plasticity and enhancing memory …
CCR5 and CCL5 gene expression in colorectal cancer ... - PubMed
网页2024年1月11日 · Our data show a strong association between CCR5/CCL5 gene expression and distinct molecular features, gene expression profiles, TME cell infiltration, and treatment benefit in CRC. Targeting the CCR5/CCL5 axis may have clinical applications in selected CRC subgroups and may play a key role in …
Biological and Clinical Significance of the CCR5/CCL5 Axis in ...
网页2020年4月5日 · To determine the biological significance of CCR5 expressed by LCa cell lines, a tissue microarray of LCas stained for CCR5 and CCL5 was analyzed. The results showed higher expression ( p < 0.001) of CCR5 and CCL5 in hepatocellular carcinoma (HCC) tissues compared to non-neoplastic liver tissues.
Targeting Autocrine CCL5-CCR5 Axis Reprograms ... - PubMed
网页2017年6月1日 · Targeting the host CCL5 in bone marrow via nanoparticle-delivered expression silencing, in combination with the CCR5 inhibitor Maraviroc, resulted in strong reductions of IMC and robust antitumor immunities. Our study suggests that the myeloid CCL5-CCR5 axis is an excellent target for cancer immunotherapy. Cancer Res; 77(11); 2857-68. ©2017 AACR
Runx-mediated regulation of CCL5 via antagonizing two …
网页2020年3月26日 · In the current study, we show concrete genetic evidence that Ccl5 expression during these distinct phases, inflammation vs. homeostasis, is regulated by two distinct enhancers, providing insights...
CCL5/CCR5/CYP1A1 pathway prompts liver cancer cells to survive …
网页2024年8月25日 · The CCL5/CCR5 axis can directly promote tumor formation, development, invasion, and metastasis, or it can indirectly aid in forming an immunosuppressive microenvironment or promote angiogenesis, tumor metabolism, chemotherapy resistance, and so on, thereby playing a crucial role in promoting tumor growth. 38-45 We performed RNAseq analysis on ...
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