The Pharmacology of CD38/NADase: An emerging target for …
网页Does BST-1, a protein homologous to CD38, play a role in organismal NAD homeostasis? Will NAD-boosting therapies be an effective way to treat or prevent age-related diseases and metabolic syndrome? Does the combination of CD38 inhibitors with NAD precursors present an advantage in NAD boosting therapy for age-related diseases?
CD38 and CD157: A long journey from activation markers to ...
网页2013年8月2日 · CD38 and its homologue CD157 (BST-1), contiguous gene duplicates on human chromosome 4 (4p15), are part of a gene family encoding products that modulate the social life of cells by means of bidirectional signals.
CD38 as a Regulator of Cellular NAD: A Novel Potential …
网页CD38 is a multifunctional enzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second messengers. Recently, CD38 was also identified as one of the main cellular NADases in mammalian tissues and appears to regulate cellular levels of NAD in multiple tissues and cells.
CD38 and Regulation of the Immune Response Cells in Cancer
网页2021年2月27日 · CD38 is a multifunctional ectoenzyme that functions as a nicotinamide adenine dinucleotide (NAD+) glycohydrolase and catalyzes the synthesis and degradation of cADPR affecting calcium signaling and release, thus decreasing extracellular NAD+, altering calcium cascade and deeply contributing to adenosine-mediated immune suppression (Figure 1), wh...
网页Of particular interest was the identification of a CD38-related gene, called BST-1 in the human (18) and BP3 in the mouse (19), that also maps to human chromosome 4 (4p15; T. Hirano, personal communication) and to mouse chromosome 5 (C. Dong, personal communication), re-spectively.
BST-1, a surface molecule of bone marrow stromal cell lines that ...
网页1994年6月7日 · The deduced amino acid sequence of BST-1 exhibited 33% identity with CD38. BST-1 was expressed in a wide range of tissues and in umbilical vein endothelial cells, whereas it was scarcely expressed in a variety of hematopoietic cell lines. The gene for BST-1 was assigned to chromosome 14q32.3, where …
An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 ...
网页2017年3月24日 · Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in the brain as a neuroregulator and affects social behaviors.
BST1 - Wikipedia
网页Bst1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis.
CD157: From Myeloid Cell Differentiation Marker to Therapeutic …
网页2019年12月5日 · First identified over 30 years ago as Mo5 myeloid differentiation antigen and 10 years later as Bone Marrow Stromal Cell Antigen 1 (BST-1), CD157 proved not to be restricted to the myeloid compartment and to have a diversified functional repertoire ranging from immunity to cancer and metabolism.
History and Perspectives of Research in Bone Marrow Stromal …
网页2014年12月1日 · cADP-ribose, which is produced by ecto-ADP-ribosyl cyclase of CD38 or bone marrow stromal cell antigen-1 (BST-1), is a key regulator of Ca2+-induced calcium...