Chromatin remodeling - Wikipedia
网页Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression.
Chromatin Modifications and Their Function - Cell Press
网页2007年2月23日 · To establish a global chromatin environment, modifications help partition the genome into distinct domains such as euchromatin, where DNA is kept “accessible” for transcription, and heterochromatin, where chromatin is “inaccessible” for transcription.
Walking through chromatin modifications | Nature Methods
网页2021年5月7日 · Chromatin is a highly organized structure composed of repeating DNA–histone complexes decorated with DNA modifications and histone post-translational modifications (PTMs). These chemical...
Regulation of chromatin by histone modifications | Cell Research …
网页2011年2月15日 · Modifications not only regulate chromatin structure by merely being there, but they also recruit remodelling enzymes that utilize the energy derived from the hydrolysis of ATP to reposition...
Systematic epigenome editing captures the context-dependent …
网页2024年5月9日 · Chromatin modifications are linked with regulating patterns of gene expression, but their causal role and context-dependent impact on transcription remains unresolved. Here we develop a modular...
Regulation of chromatin structure and function: insights into the ...
网页2021年2月16日 · Chromatin remodeling refers to a wide range of chromatin changes induced by chromatin-remodeling factors interacting with nucleosomes, which can be achieved by various means, including (i) ATP-dependent remodeling complexes, (ii) histone posttranslational modifications, (iii) histone chaperones, and (iv) the interplay of all three .
Chromatin Modifiers in Transcriptional Regulation: New Findings …
网页2020年7月28日 · In this review, we discuss current trends in the study of histone modifiers and chromatin remodelers, including the functional impact of transcriptional proteins/ complexes i.e., “pioneers”; remodeling and modification of non-histone proteins by transcriptional complexes; the supplementary functions of the non-catalytic subunits of remodelers, a...
Spatial-CUT&Tag: Spatially resolved chromatin modification
网页2022年2月10日 · Deng et al. report on a technique called spatial-CUT&Tag for genome-wide profiling of histone modifications pixel by pixel on a frozen tissue section without dissociation. This method resolved spatially distinct and cell-type-specific chromatin modifications in mouse embryonic organogenesis and postnatal brain development.
Chromatin modifications and their function - PubMed
网页2007年2月23日 · Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Chromatin Manipulation and Editing: Challenges, New …
网页2021年1月6日 · Besides being structurally important to enable DNA fitting into the nucleus, chromatin represents an inherent barrier for all DNA-based processes, thereby rendering all genome-related functions (e.g., transcription, replication, DNA repair and recombination) dependent on changes in histone-DNA and/or histone-histone contacts inside the …