E2A-regulated epigenetic landscape promotes memory CD8 T cell ...
网页2021年4月4日 · E2A Overexpression Promotes Memory CD8 T Cell Formation. To test whether E2A activity could enhance the formation of virus-specific memory CD8 T cells in vivo, we transferred transduced P14 cells to mice and infected them with LCMV Armstrong.
The function of E- and id proteins in lymphocyte development
网页2001年12月1日 · E2A proteins act as attenuators of thymocyte positive selection. Signals initiated by the crosslinking of the T-cell receptor (TCR) complex and transmitted through the RAS–ERK–MAP kinase...
E2A-regulated epigenetic landscape promotes memory CD8 T cell …
网页2021年4月20日 · In this study, we explore the transcriptional changes during effector and memory CD8 T cell differentiation at the single-cell level. Using single-cell, transcriptome-derived gene regulatory network analysis, we identified two main groups of regulons that govern this differentiation process.
The opposing roles of the transcription factor E2A and its ... - Nature
网页2011年8月21日 · Together our observations demonstrate on a global scale how E2A orchestrates T cell development, whereas Id3 acts to maintain the naive T cell fate.
E Protein Transcription Factors as Suppressors of T Lymphocyte …
网页2022年4月20日 · In this review, we discuss the role of E2A in T cell development and how alterations in E protein function underlie leukemogenesis. We focus on the role of TAL1 and LYL1 and the genes that are dysregulated in E2a-/-T cell progenitors that contribute to human T-ALL. These studies reveal novel mechanisms of …
The transcription factor E2A activates multiple enhancers that …
网页E2A bound to discrete distal regulatory elements in pro-T and pro-B cells that were associated with assay for transposase-accessible chromatin (ATAC-seq) signals and p300 binding in a cell type–specific manner .
A global network of transcription factors, involving E2A, EBF1 and ...
网页2010年6月13日 · In thymocyte development, both E2A and PTEN enforce the pre–T cell antigen receptor checkpoint 38,39. Finally, PTEN, Foxo and E2A act to prevent the development of T cell lymphoma...
The opposing roles of E2A and Id3 that orchestrate and enforce …
网页Genome-wide E2A occupancy orchestrates T-cell fate. As a first approach to determine how E2A and Id3 contribute to establish the αβ-T lineage we examined the global distribution of E2A bound sites in the DN3 and DN4 compartments.
E2A proteins enforce a proliferation checkpoint in developing ...
网页2003年12月11日 · E2A proteins regulate multiple stages of thymocyte development and suppress T‐cell lymphoma. The activity of E2A proteins throughout thymocyte development is modulated by signals emanating from the pre‐TCR and TCR.
The transcription factor E2A activates multiple enhancers that …
网页2020年9月4日 · By mapping cis-regulatory elements and generating multiple mouse strains lacking distinct enhancer elements, we demonstrate expression of Rag genes in developing T and B cells to be driven by distinct sets of E2A-dependent cis-regulatory modules.