E2F1在常见肿瘤中的最新研究进展 - PMC - National Center for ...
网页2020年10月10日 · The cell cycle-related transcription factor E2F1 is a member of the cell cycle-related transcription factor E2F family, mainly involved in various cell processes including cell cycle progression, DNA repair, DNA replication, cell differentiation, proliferation, and apoptosis.
Context-Dependent Functions of E2F1: Cell Cycle, Cell Death
网页E2F1 overexpression led to cell cycle activation and acute neuronal apoptosis without detectable entry of the neurons into S phase. ChIPseq analysis demonstrated that E2F1 predominantly occupies positions on or near the promoters of cell cycle related genes. Instead, in CPT-treated neurons, E2F1 preferentially regulated DNA repair related genes.
E2F1 promotes cell cycle progression by stabilizing spindle fiber …
网页2022年10月11日 · Background: E2F1 is a transcription factor that regulates cell cycle progression. It is highly expressed in most cancer cells and activates transcription of cell cycle-related kinases. Stathmin1 and transforming acidic coiled-coil-containing protein 3 (TACC3) are factors that enhance the stability of spindle fiber.
E2F1 facilitates DNA break repair by localizing to break sites and ...
网页2019年9月18日 · These mechanisms preserve efficient cell cycle progression and genomic integrity in colon cancer cells by using high-fidelity HR pathways to repair DSBs and ssDNA gaps to overcome the...
Cryptochromes modulate E2F family transcription factors
网页2020年3月5日 · Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and...
The broken cycle: E2F dysfunction in cancer - Nature
网页2019年5月3日 · Activator protein (E2F1, E2F2 and E2F3A) levels peak at the G1–S phase transition, and atypical repressor (E2F7 and E2F8) levels peak later in late S phase, whereas canonical repressor (E2F3B ...
RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in …
网页2021年9月1日 · Biochemical and functional assessment using both in vitro and in vivo models identified an unexpected, prominent role for E2F1 in regulation of redox metabolism after RB loss, driving an increase in the synthesis of the antioxidant glutathione, specific to advanced disease.
Emerging Role of E2F Family in Cancer Stem Cells - PMC
网页2021年8月12日 · According to initial reporter gene detection and evaluation of their expression patterns during the cell cycle, E2Fs have been classified as transcriptional activators (E2F1-3) or transcriptional repressors (E2F4-8) (Figure 1), and are thus predicted to play a dual role in human cancers (8, 9).
E2F1, a Novel Regulator of Metabolism - PubMed
网页2017年11月10日 · The transcription factor E2F1 is a central player involved in cell cycle progression, DNA-damage response, and apoptosis. Its crucial role in the control of cell fate has been extensively studied and reviewed before; however, here, we focus on the participation of E2F1 in the regulation of metabolism.
E2F1, a Novel Regulator of Metabolism - Frontiers
网页2017年11月10日 · The transcription factor E2F1 is a central player involved in cell cycle progression, DNA-damage response, and apoptosis. Its crucial role in the control of cell fate has been extensively studied and reviewed before; however, here, we focus on the participation of E2F1 in the regulation of metabolism.
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