G protein-coupled receptors (GPCRs): advances in structures, …
网页2024年4月10日 · The glucagon-like peptide-1 receptor (GLP-1R) is a peptide hormone class B GPCR whose activation stimulates the glucose-dependent stimulation of insulin and decreases glucagon...
G protein-coupled receptors as regulators of glucose ... - PubMed
网页As critical regulators of almost all physiological processes in the body, G protein-coupled receptors (GPCRs) are important regulators of glucose homeostasis. Some of the newer drugs for treating diabetes mellitus or in development are also targeting GPCRs. This chapter provides a summary of some of ….
G protein-coupled receptors (GPCRs): advances in structures, …
网页2024年4月10日 · G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface membrane receptors and are encoded by approximately 1000 genes, sharing conserved seven-transmembrane (7TM) helices connected by three intra- and three extra-cellular loops. 1–3 GPCRs are conformationally dynamic proteins that mediate vital biological functions of ...
G protein-coupled receptor 151 regulates glucose metabolism
网页2022年12月1日 · Recently a rare, putative loss-of-function mutation in the orphan G-protein coupled receptor 151 (GPR151) was found to be associated with lower odds ratio for type 2 diabetes, but the mechanism ...
G Protein-Coupled Receptors: A Century of Research and Discovery
网页2024年6月21日 · GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) are 2 peptide hormones released by the gut that are responsible for mediating increased insulin secretion by the pancreas in response to an oral glucose load.
GPCR Signaling Pathways in Metabolism - National Center for ...
网页2021年8月23日 · G protein-coupled receptors (GPCRs) regulate virtually all metabolic processes, including glucose and energy homeostasis. In this review, we focus on GPCRs that function in metabolic disorders, particularly in T2D and obesity-related diseases.
Revealing the tissue-level complexity of endogenous glucagon …
网页2023年1月18日 · The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are...
G Protein-Coupled Receptors as Regulators of Glucose
网页2014年1月1日 · Numerous GPCRs regulate different aspects of glucose homeostasis, including insulin and incretin secretion, glucose uptake, and fat metabolism. Historically, GPCRs have proven to be very successful therapeutic targets.
G-protein-coupled receptors (GPCRs) in the treatment of …
网页2018年4月1日 · G-Protein Coupled Receptors (GPCRs) are the largest receptor family in the genome. Due to their intrinsic properties, GPCRs represent the target of almost 30% of approved therapeutic drugs, including some currently used in type 2 diabetes treatment.
GPCRs, G Proteins, and Their Impact on β-cell Function
网页2020年3月12日 · Glucose-induced (physiological) insulin secretion from the islet β-cell involves interplay between cationic (i.e., changes in intracellular calcium) and metabolic (i.e., generation of hydrophobic and hydrophilic second messengers) events.
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