Structure and Function of the HIV Envelope Glycoprotein as Entry ...
网页2007年6月21日 · The HIV envelope glycoprotein (Env) binds to cell surface–associated receptor (CD4) and coreceptor (CCR5 or CXCR4) by one of its two noncovalently associated subunits, gp120. The induced conformational changes activate the other subunit (gp41), which causes fusion of the viral with the plasma cell membranes resulting in …
HIV: Cell Binding and Entry - PMC - National Center for …
网页To infect cells, the HIV protein envelope (Env) binds to the primary cellular receptor CD4 and then to a cellular coreceptor. This sequential binding triggers fusion of the viral and host cell membranes, initiating infection.
How membrane physics rules the HIV envelope - Nature
网页2019年4月1日 · HIV particles incorporate host membrane proteins into their envelope to evade the immune system and infect other cells. A study now shows that Gag assembly on the host cell membrane produces a...
HIV envelope: challenges and opportunities for development of …
网页2011年3月4日 · The HIV envelope is an attractive target for therapeutic and immunological intervention of HIV entry as discussed above.
Microsecond dynamics control the HIV-1 Envelope conformation
网页2024年2月2日 · The HIV-1 Envelope (Env) glycoprotein mediates viral attachment and entry into host cells (1, 2). This is accomplished through a complex series of receptor CD4 and co-receptor CCR5/CXCR4-induced Env structural transitions that ultimately result in virion-host cell membrane fusion and host cell infection (3 – 5).
HIV envelope: challenges and opportunities for development …
网页The HIV envelope proteins glycoprotein 120 (gp120) and glycoprotein 41 (gp41) play crucial roles in HIV entry, therefore they are of extreme interest in the development of novel therapeutics. Studies using diverse methods, including structural biology and mutagenesis, have resulted in a detailed model for envelope-mediated entry, which consists ...
Structural basis of transmembrane coupling of the HIV-1 envelope ...
网页2020年5月8日 · HIV-1 envelope glycoprotein (Env) mediates the fusion of viral and target cell membranes and is a major target for HIV vaccine development.
HIV-1 Envelope Conformation, Allostery, and Dynamics
网页2021年5月7日 · The HIV-1 envelope glycoprotein (Env) mediates host cell fusion and is the primary target for HIV-1 vaccine design. The Env undergoes a series of functionally important conformational rearrangements upon engagement of its host cell receptor, CD4. As the sole target for broadly neutralizing antibodie ….
Global site-specific N-glycosylation analysis of HIV envelope ...
网页2017年3月28日 · HIV-1 envelope glycoprotein (Env) is the sole target for broadly neutralizing antibodies (bnAbs) and the focus for design of an antibody-based HIV vaccine.
Molecular Mechanism of HIV-1 Entry - PubMed
网页HIV-1 envelope glycoprotein [Env; trimeric (gp160)<sub>3</sub> cleaved to (gp120/gp41)<sub>3</sub>] attaches the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate infection. It interacts with the primary receptor CD4 and coreceptor (e.g., chemokine receptor CCR5 ….
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