Understanding HIV Latency: The Road to an HIV Cure
网页Here, we review molecular mechanisms that have been proposed to contribute to HIV latency, as well as the relative roles of cis- and trans-acting mechanisms. We also discuss existing and future therapeutic opportunities regarding HIV latency that might lead to a future cure for HIV infection.
HIV latency - Wikipedia
网页Human Immunodeficiency Virus (HIV) has the capability to enter a latent stage of infection where it exists as a dormant provirus in CD4+ T-cells. Most latently infected cells are resting memory T cells, [1] however a small fraction of latently infected cells isolated from HIV patients are naive CD4 T cells. [2] Molecular Control of HIV Latency.
HIV Latency - PMC - National Center for Biotechnology Information
网页HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4 + T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression.
What is a Latent HIV Reservoir? | NIH - HIVinfo
网页A latent HIV reservoir is a group of immune system cells in the body that are infected with HIV but are not actively producing new HIV virus particles. Finding ways to target and either destroy or silence latent reservoirs is a major challenge facing HIV researchers who are exploring different strategies for curing HIV infection.
The Stages of HIV Infection | NIH
网页2021年8月20日 · The second stage of HIV infection is chronic HIV infection (also called asymptomatic HIV infection or clinical latency). During this stage, HIV continues to multiply in the body but at very low levels.
2. HIV Latency and Potential Agents for Reversal - National …
网页2021年2月23日 · HIV latency is a major problem that has been recognized since the introduction of combined antiretroviral therapy (ART) to inhibit viral replication and disease progression. Latently HIV-infected patients on ART may contain as low as one copy of provirus incorporated into the genome of host cells [1].
Research priorities for an HIV cure: International AIDS ... - Nature
网页2021年12月1日 · Since the discovery that HIV can establish a latent infection with minimal HIV transcription, a range of approaches has emerged that specifically target latently infected cells.
Understanding HIV-1 latency provides clues for the eradication
网页Latent HIV-1 reservoirs are established early during primary infection in CD4 + T cells and constitute a major barrier to HIV-1 eradication, even in the presence of highly active...
Deep latency: A new insight into a functional HIV cure
网页2019年5月22日 · Several strategies have been proposed to combat HIV latency, including bone marrow transplantation to replace blood cells with CCR5-mutated stem cells, gene editing to disrupt the HIV genome, and “Shock and Kill” to reactivate latent HIV followed by an immune clearance.
An Integrated Overview of HIV-1 Latency - Cell Press
网页2013年10月24日 · Latency is established early during acute infection, likely within days of initial infection (Chun et al., 1998a). Although transcriptionally silent, this reservoir is fully capable of producing infectious virus when the host cell is reactivated by recall antigen or various cytokines or when antiretroviral therapy (ART) is discontinued.