Mast cell secretory granules: armed for battle - Nature
网页2014年6月6日 · Mast cell secretory granules are lysosome-like organelles that contain a large panel of preformed bioactive constituents, including lysosomal hydrolases, amines, cytokines,...
Mast cell - Wikipedia
网页A mast cell (also known as a mastocyte or a labrocyte[1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
Mast Cell Mediators: Their Differential Release and the Secretory ...
网页2014年11月14日 · Mast cells granules, also called secretory lysosomes, contain both lysosomal proteins such as acid hydrolases, e.g., β-hexosaminidase, as well as mediators such as histamine, and can secrete both together. MC also contain traditional lysosomes that can release enzymes such as β-hexosaminidase independently of histamine .
Mast cell secretory granules: armed for battle - PubMed
网页Mast cells are distinguished by their high content of electron-dense secretory granules, which are filled with large amounts of preformed and pre-activated immunomodulatory compounds. When appropriately activated, mast cells undergo degranulation, a process by which these preformed granule compounds are rapidly released into the surroundings.
Histology, Mast Cells - StatPearls - NCBI Bookshelf
网页2023年5月1日 · Mast cells are oval or irregularly shaped cells. Under light microscopy, a dense granular cytoplasm is seen, often obscuring the nucleus and other organelles. When it can be visualized, the nucleus is central, and the cell is mononuclear. Mast cells are found throughout the body in loose connective tissue.
Mast Cell: A Multi-Functional Master Cell - PMC - National Center …
网页2016年1月6日 · Mast cells are located in areas below the epithelium in connective tissue surrounding blood cells, smooth muscle, mucous, and hair follicles. The cytoplasm of the mast cell contains 50–200 large granules that store inflammatory mediators, including histamine, heparin, a variety of cytokines, chondroitin sulfate, and neutral proteases .
Mast cell granules: Modulating adaptive immune response …
网页Owing to their localization at barrier interfaces and the readily available ammunition of preformed granules, mast cells are perfectly poised to regulate immune responses during infections.
Synthetic mast-cell granules as adjuvants to promote and polarize ...
网页2012年1月22日 · Granules of mast cells (MCs) enhance adaptive immunity when, on activation, they are released as stable particles. Here we show that submicrometre particles modelled after MC granules...
New perspectives on the origins and heterogeneity of mast cells
网页2022年5月24日 · In the evolutionary tree of life, cells that resemble mast cells, having granules made of heparin complexed with serine proteases, are found as early as in invertebrate tunicates 1, 2 (Fig....
Mast cell secretory granule fusion with amphisomes coordinates …
网页Mast cell secretory granules (SGs) enlarge via Rab5-regulated fusion. Omari et al. found that SGs enlarge by fusion of individual SGs with amphisomes and decrease in size through dynamin-mediated fission regulated by phosphoinositide interconversions. While both small and large SGs are exocytosis competent, only large SGs can release exosomes.