Psoralen: a narrative review of current and future therapeutic uses
网页2024年3月15日 · Psoralen has demonstrated its utility in the treatment of various cancers, leveraging its photoreactive properties and specific targeting of highly active, replicating cells. The initial case report detailing the use of Psoralen in …
Malignancy risk and recurrence with psoriasis and its treatments: a ...
网页Several studies found oral psoralen and ultraviolet A (PUVA) to be associated with increased risk of skin cancer in a dose dependent fashion[18–21] but not for non-cutaneous malignancies. The risk of NMSC is greatest with >350 treatments, genital SCC risk is increased and persisted after cessation of treatment[ 23 , 24 ].
The Impact of Psoriasis Treatments on the Risk of Skin Cancer: A ...
网页2024年8月28日 · Some psoriasis treatments, such as psoralen and ultraviolet A (PUVA) therapy and cyclosporine, have been associated with increased risk of skin cancer.
Effects of psoriasis and psoralen exposure on the somatic ... - Nature
网页2023年10月26日 · We looked for evidence of the psoralen signature both in TCGA melanoma samples and in skin cancers from the HMF and found evidence of the signature only in a psoriasis patient with a history...
Multiple Skin Cancers Following Psoralen and Ultraviolet A …
网页2014年12月23日 · Of these, the combination of psoralen and ultraviolet A (PUVA) has been used widely as an effective means to induce remission of psoriasis, but high-dose PUVA is reported to increase the risk of skin cancer . In this report, we present a patient with psoriasis under long-term high-dose PUVA therapy …
网页Psoralen is a family of naturally occurring photoactive compounds found in plants that acquire potential cytotoxicity when activated by specific frequencies of electromagnetic waves. Psoralens penetrate the phospholipid cellular membranes and insert themselves between the pyrimidines of deoxyribonucleic acid (DNA).
Psoralen: a narrative review of current and future therapeutic uses
网页Thus, the cytotoxicity of photoactivated psoralen holds promising clinical applications from its immunogenic properties to potential anti-cancer treatments. This narrative review aims to provide an overview of the current understanding and research on psoralen and to explore its potential future pharmacotherapeutic benefits in specific diseases.
Psoralen: a narrative review of current and future therapeutic uses
网页2024年3月15日 · Psoralen is a family of naturally occurring photoactive compounds found in plants that acquire potential cytotoxicity when activated by specific frequencies of electromagnetic waves....
Psoralen plus ultraviolet A (PUVA) photochemotherapy
网页2022年12月1日 · Psoralen plus ultraviolet A (PUVA) photochemotherapy combines the administration of psoralens, a class of phototoxic plant-derived compounds, with an exposure to ultraviolet A radiation (UVA). PUVA is used for the treatment of a variety of skin diseases, including psoriasis, mycosis fungoides, …
Incidence and profile of skin cancers in patients following …
网页Overall, there were 170 skin cancers (17 melanomas, 33 SCCs, and 120 BCCs) identified in 79 patients post phototherapy. The anatomical distribution of skin cancers was mostly on the head and neck as per the general population. Skin cancer incidence increased with age and decreased with higher Fitzpatrick skin phototypes.
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