The AKT/mTOR signaling pathway plays a key role in statin …
网页The current studies were performed to explore the down-stream effects of the statin-associated inhibition of AKT within the AKT signaling pathway and on myocyte biology and morphology in C2C12 myotubes and in mice in vivo. We exposed C2C12 myotubes to 10 μM or 50 μM simvastatin, atorvastatin or rosuvastatin for 24 h.
Statins Decrease Programmed Death-Ligand 1 (PD-L1) by Inhibiting AKT ...
网页2021年9月20日 · Four statins, namely simvastatin, atorvastatin, lovastatin, and fluvastatin, decreased PD-L1 expression in melanoma and lung cancer cells. In addition, we found that AKT and β-catenin signaling involved PD-L1 suppression by statins.
The AKT/mTOR signaling pathway plays a key role in statin …
网页2015年8月1日 · The current study demonstrates that statins are cytotoxic and impair AKT phosphorylation in C2C12 myotubes and in skeletal muscle of mice in vivo. The lipophilic simvastatin and atorvastatin showed a higher in vitro toxicity than the …
The HMG-CoA reductase inhibitor simvastatin activates the …
网页We show here that statins rapidly activate the protein kinase Akt/PKB in endothelial cells. Accordingly, simvastatin enhanced phosphorylation of the endogenous Akt substrate endothelial nitric oxide synthase (eNOS), inhibited apoptosis and accelerated vascular structure formation in vitro in an Akt-dependent manner.
Simvastatin Inhibits Renal Cancer Cell Growth and Metastasis via AKT …
网页2013年5月17日 · We found that inhibition of AKT activation by knockdown of AKT expression sensitized renal cancer cells to simvastatin-induced anti-cancer effect. Furthermore, it has been reported that AKT exerts its biological effect by phosphorylating its downstream substrates including mTOR.
Simvastatin Increases Phosphorylation of Akt and its …
网页Based on our findings we propose that treatment with simvastatin increases phosphorylation of Akt in the neuronal cells after TBI, followed by phosphorylation of its downstream targets FOXO, IκB and eNOS, which eventually leads to anti-apoptotic effects partially through suppressing caspase 3 activity.
Simvastatin improves the homing of BMSCs via the PI3K/AKT…
网页2016年2月12日 · Simvastatin has complex effects on the PI3K/AKT signalling pathway in different cell types, and we determine whether simvastatin activates AKT in BMSCs. We found that AKT phosphorylation increased with increasing concentrations of simvastatin.
The HMG-CoA reductase inhibitor simvastatin activates the …
网页2001年1月1日 · Simvastatin induces Akt-mediated phosphorylation of eNOS, leading to NO production, and promotes endothelial cell survival in an Akt-dependent manner.
Regulatory effects of statins on Akt signaling for prevention of ...
网页2024年8月1日 · Jang et al. evaluated the effect of statin on the Akt signaling pathway in different AML cell lines. They indicated that simvastatin inhibits the Akt activity in THP1 AML cells. Also, they reported that the combination therapy of simvastatin with MEK inhibitor reduced the proliferation of THP1 AML cells more than simvastatin alone [193].
Insulin prevents and reverts simvastatin-induced toxicity in …
网页2019年5月15日 · The experiment shows the important role of Akt activation for the prevention of cell death and suggests that the effect of simvastatin on Akt is not direct and can be circumvented by insulin...
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