Cell Metabol：揭示调节机体致病突变遗传背后的特殊DNA机制
在几乎所有真核生物中，线粒体DNA（mtDNA）都能编码氧化磷酸化所需的蛋白以及合成这些蛋白所需的RNAs，目前研究人员并不是非常清楚mtDNA拷贝数和表达的调节机制，但至关重要的是，研究人员确定了细胞核和mtDNA编码亚基的OXPHOS复合体的正确化学计量组装机制。 近日，一篇发表在国际杂志Cell Metabolism上题为“Misregulation of mitochondrial 6mA ...
The EMBO Journal8 天
An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress
FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...
The EMBO Journal5 天
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis ...
How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...
emjreviews.com9 天
The Importance of Early Recognition, Diagnosis, and Treatment of Friedreich Ataxia
This industry-sponsored symposium took place during the European Association of Neurology (EAN) Congress held in Helsinki, Finland, 29 June−2 July, 2024.