两项研究均表明了自噬体（autophagosome）是以一种选择性的、受体-蛋白介导的方式来调控内质网的降解。 由德国法兰克福大学医学院生物化学教授Ivan Dikic领导的一个研究小组成功地破译了一些分子细节，将帮助人们更好地了解两种神经退行性疾病。他们将研究的 ...

Time-lapse studies provide compelling images which suggest that autophagosome formation proceeds in a step-wise manner, marked by the expansion of the sequestering membrane 10 (Supplementary ...

Scientists say activation of our cellular cleanup crew can be observed after just 20 to 30 repetitions of this exercise.

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

This study uncovers how oligodendroglial lipid metabolism supports myelin homeostasis and axonal function under metabolic ...

The protein BAG3 plays a critical role in the elimination of damaged components, identifying these and ensuring that they are enclosed by cellular membranes to form an "autophagosome ...

The protein BAG3 plays a critical role in the elimination of damaged components, identifying these and ensuring that they are enclosed by cellular membranes to form an "autophagosome ...