Although glucose is the main mediator of glucagon secretion ... these circulating factors and insulin/glucagon secretion are GPCRs, which in islets mediate the effects of many of the circulating ...

San Diego’s Dexcom began sales this week of Stelo, the industry’s first FDA-approved continuous glucose monitor that doesn’t require a prescription. With a two-pack of the biosensor costing ...

Explore how peptide drugs are changing the hundred-billion-level weight loss market, and how this landscape is changing as ...

Luminal nutrients stimulate enteroendocrine cells (EEC) to release mediators that potently inhibit appetite and promote glucose homeostasis. Several specific G-protein-coupled nutrient receptors (GPCR ...

Most protein-targeting drugs are prizes that drug developers have unearthed from G protein–coupled receptor (GPCR) interactomes. So, when GPCR-targeting drugs become harder to find, one might ...

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In particular, GPCRs play essential roles in the central nervous system, including neurotransmission and neuronal metabolism, as well as in energy homeostasis, including modulation of insulin ...

NVO stock gains 4.2% after it presents efficacy data superior to Wegovy for its new oral pill, amycretin, in an early-stage ...

We also develop phototropin and cryptochrome-based optogenetic tools for regulating G protein signaling independent of GPCRs. These engineered tools ... by insulin and its receptors to control ...