University of Cologne scientists identified histone H1.2 and PARP1 as potential therapeutic targets in ALS. Inhibiting these proteins reduced neurodegeneration in both human motor neurons and C.

Scientists have found that the protein histone H1.2 and the enzyme PARP1 could be potential therapeutic targets to decrease neurodegeneration in amyotrophic lateral sclerosis (ALS). Amyotrophic ...

可通过条带的迁移率差异，指示磷酸化蛋白的磷酸化水平。 1.SDS-PAGE胶中的Phos-tag™ 捕获磷酸化蛋白。 2. 电泳中的磷酸化蛋白的泳动速度变慢。 3. 根据磷酸化水平出现在上移后的位置，分离出磷酸化蛋白的条带。 Phos-tag™ 由日本广岛大学研究生院 医齿药学 ...

The linker histones, H1 and its variant forms ... This led to the prediction that the linker histone may interfere with TFIIIA binding. Figure 2: Diagrams summarizing two alternative models ...

The study was published under the title "ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes" in Cell Reports. The two proteins that ...

1998). Interestingly, histone H1 is very important in stabilizing chromatin higher-order structures, and 30-nanometer fibers form most readily when H1 is present. Processes such as transcription ...

The study was published under the title 'ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to ...

Epub 2019 Aug 2. Prescott NA and David Y. Utilizing intein trans-splicing for in vivo generation ... A Robust Method for the Purification and Characterization of the Human Histone H1 Variants.

PMID: 890579 Chan, P.K. and Liew, C.C.: Identification of nonhistone chromatin proteins in chromatin subunits (or mononucleosomes) devoid of histone H1. Can. J. Biochemistry 57: 666 672 (1979 ...