自噬是真核细胞中的一种关键的细胞内降解过程，负责清除衰老的蛋白质和功能异常的细胞器，从而维持细胞的稳态。在癌症治疗中，自噬的作用是多方面的，取决于肿瘤的类型和肿瘤发生的阶段。一方面，自噬作为一种肿瘤抑制机制，通过消除整合细胞成分来发挥作用。另一方面， ...

为了探索唑喹达下调PD-L1的分子机制，研究人员研究了唑喹达对PD-L1蛋白稳定性和mRNA水平的影响。研究人员发现唑喹达显著缩短了PD-L1蛋白的半衰期，而对mRNA水平没有影响。此外，与蛋白酶体抑制剂MG132相比，溶酶体抑制剂NH4Cl抑制了唑 ...

PI3P组装WIPI蛋白和DFCP 1以促进初始吞噬团形成。对于吞噬细胞来说，细胞质货物通过选择性自噬受体（SAR）招募。LC3被ATG4蛋白分解形成LC3-I。由ATG7 ...

The LC3-Skifter is a unique item needed to unlock one of the more useful abilities in Star Wars Outlaws. The LC3-Skifter can only be found in one place, so the guide below will tell you what it ...

Lipidated ATG8/LC3 proteins are recruited to single membrane compartments as well as autophagosomes, supporting their functions. Although recent studies have shown that Golgi-LC3 lipidation follows ...

研究人员报道的最新发现指出，在血管紧张素II（Ang II）处理过的心肌细胞和肥大心脏中，免疫蛋白酶体催化亚基β5i表达和活性显著增加，而且这种作用在心肌细胞和转基因小鼠中通过β5i过表达 ...

Modified configure to compile on Mac OS X, especially Lion, but should be compatible with Leopard/Snow Leopard. /usr/bin/gcc is a bit of a frankencompiler on Lion; it's actually an alias for ...

When delivered into lysosomes by autophagy, pulse-labeled Halo-based reporters (e.g. Halo-LC3 and Halo-GFP) are proteolytically processed to generate Halo ligand when delivered into lysosomes by ...

One of the key characteristics of Bluetooth LE Audio is the new high performing standards-based LC3 audio codec. LE Audio requires the LC3 codec which supports scaling from 345kbps to just 16kbps ...

与单独使用αCLDN18.2-MMAE相比，联合使用自噬抑制剂LY294002导致LC3-II蛋白表达显著降低，SQSTM1蛋白表达显著升高，表明有效抑制了自噬。如图1B和D所示 ...