The team of Professor Christof Niehrs at the Institute of Molecular Biology (IMB) in Mainz, Germany, has discovered that a ...

DNA methylation, essential for regulating gene expression and cell function, is crucially maintained by CDCA7, which ...

D NA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and is a major ...

Cytosine can undergo chemical modifications that play crucial roles in gene regulation and epigenetics. The most common modification is the addition of a methyl group to carbon 5, forming ...

Subscribe for FREE For decades, scientists thought that vertebrates had only one type of epigenetic modification on DNA ...

Other studies have shown that the promoter regions of genes become more methylated in cancer cells. In humans, cytosine often becomes methylated when it is next to a guanosine—this arrangement ...

A) Within the genome, the majority of CpG pairs are methylated by addition of –CH 3 to cytosine. B) DNA methylation involves conversion of unmethylated cytosine to 5-methyl-cytosine (5mC). A proposed ...

An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene ...

Post implantation, de novo methylation begins (red circles), mediated primarily by DNA (cytosine-5-)-methyltransferase-3alpha (DNMT3A) and -3beta (DNMT3B) (top). When methylation affects CpG ...

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and a major way that DNA is epigenetically marked. Epigenetic modifications can act as on ...

CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA. DNA methylation is a process in which a methyl group is ...