Prenylation represents a critical step in the biosynthesis of many natural products. A new study reveals how aromatic prenyltransferase enzymes tolerate diverse aromatic polyketides while still ...

Historically, most people started HIV treatment with two drugs from the NRTI class combined with either one NNRTI, one protease inhibitor or one integrase inhibitor – hence, ‘triple therapy’.

Changes clinical practice: The risks and benefits of adjuvant aromatase inhibitors (AIs) should be weighed carefully, especially in postmenopausal women with early-stage, hormone-receptor positive ...

Rust preventatives and corrosion inhibitors are lubricants, greases, oils, or fluid additives that form a protective film or barrier to prevent the formation of rust or corrosion. They often have ...

Citation: SGLT2 inhibitor empagliflozin is shown to be safe and effective for treating patients who have suffered a heart attack (2024, September 2) retrieved 20 September 2024 from https ...

Since the first US Food and Drug Administration approval of a Janus kinase (JAK) inhibitor in 2011, the number of these medications available — and their treatment indications — have continued ...

Citation: PARP1 selective inhibitor yields potent and durable antitumor activity in patient-derived preclinical models (2024, September 3) retrieved 19 September 2024 from https://medicalxpress ...

We work to elucidate the molecular mechanisms involved in tumour cell-bone cell interactions, and how these can be targeted by anti-cancer therapies, including CDK4/6 inhibitors. We also investigate ...