造血干细胞和祖细胞（hematopoietic stem and progenitor cell, HSPC）一生都在制造成熟的血细胞。在此过程中，造血干细胞与骨髓壁龛中的多种细胞（包括巨噬细胞）相互作用。这些巨噬细胞通过释放细胞因子和趋化因子以及巡逻来清除遭受应激、死亡或老化的细胞 ...

TNBC患者同样表现出不同的TiBA模式，并且，TiBA与三阴性乳腺癌（TNBC）病人接受新辅助免疫治疗的预后密切相关。跟踪接受化疗联合免疫检查点阻断疗法的治疗反应发现，TiBA-1和TiBA-2患者达到完全病理反应的比例显著低于TiBA-0患者。该 ...

Researchers at ETH Zurich have used a drug screening platform they developed to show that an antidepressant, currently on the ...

近日，复旦大学脑科学研究院的解云礼团队在权威期刊The EMBO Journal发表了题为 “Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction (转录因子TCF4介导的细胞命运决定调控星形胶质细胞在大脑皮层中的分布机制)” 的文章 ...

前列腺癌（Prostate cancer, PCa）是威胁中老年男性健康的主因之一。在2024年全球男性肿瘤发病率和死亡率统计中，PCa分别排第二和第五位[1]。雄激素和雄激素受体（Androgen ...

The study investigates the role of autophagy in hepatic progenitor cells (HPCs) and its potential to modulate exosomal ...

Astrocytes in the brain exhibit significant regional diversity, but the mechanisms controlling their heterogeneity remain ...

Scientists have perfected the recipe to convert giant panda skin cells into stem cells to study the animal’s biology and aid ...

Researchers have uncovered a novel mechanism underlying the skeletal reduction and asymmetry of emu wings. Their research ...

Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the ...

Dr. Tilman explains the functions of iPSC-derived microglia and their relevance to conditions like Alzheimer’s.