Goodman and her colleagues found that even a 50 percent loss of healthy tau is sufficient to disrupt lipid droplets and ...

New therapeutic opportunities often emerge from research on simple organisms. For instance, the 2020 Nobel Prize in Chemistry ...

These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...

“Copper also helps protect cells from harmful molecules termed reactive oxygen species, or ROS, which in excess can damage proteins and DNA, ultimately driving cell death, including neurons that die ...

Bile acids are byproducts of cholesterol metabolism in the liver and constitute the primary components of bile. Disruption of ...

Researchers investigate the anti-inflammatory and anti-prostate cancer properties of aged black garlic extract.

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

A new bioprocessing technique developed by a team of researchers could improve a range of therapies based on CAR-T cells.

Nuvalent achieved positive data from the phase 1/2 ALKOVE-1 study using NVL-655 for the treatment of patients with ALK-mutant ...

皮肤黑色素瘤的发病率和死亡率存在性别差异，随着年龄的增长和在男性中不成比例。然而，潜在的机制仍不清楚。虽然已经评估了肿瘤细胞的生物性别差异和固有免疫反应变异性，但肿瘤周围微环境在衰老过程中的作用一直被忽视。

The inhibition of ERK5 is a potential complementary strategy for countering FAK inhibitor resistance in patients with lung ...