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Cancer Res:靶向YAP活性和谷氨酰胺代谢通过阻止细胞外基质积累协同 ...
本研究结果表明,抑制谷氨酰胺的可用性通过降低cAMP/ pka依赖性LATS磷酸化导致癌细胞中YAP的激活,从而通过与邻近成纤维细胞的相互作用促进ECM沉积。
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