mRNA is highly unstable, generally considered to require a tiny capsule, such as lipid nanoparticles (LNPs), for administration. The method reported here is the first naked mRNA vaccine ...

但鲜少人知道mRNA疫苗的幕后功臣---将mRNA封装并且安全有效地送进机体细胞的脂质纳米颗粒（Lipid Nanoparticle，LNP）。 实际上，利用mRNA-LNP治疗癌症患者一直是十分火热的研究领域，该领域的发展甚至远早于将该技术应用于新冠疫苗的开发。虽然目前还没有临床 ...

Lipid nanoparticles (LNPs) transport small molecules into the body. The most well-known LNP cargo is mRNA, the key constituent of some of the early vaccines against COVID-19. But that is just one ...

have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine ...

Keep learning. Excel in your career. Choose from more than 200 courses in seven different categories, taught by experts in the chemistry community, online and in person.

More information: Jenny A. Greig et all, Lipid Nanoparticle mRNA Therapy Improves Survival and Reduces Serum Branched-Chain ...

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications ...

such as direct injection of naked mRNA, lipid-based carriers, polymers, and protein derivatives. Those COVID vaccines that have experienced success are based around lipid nanoparticle delivery.

Our more recent observations indicate that certain oxidized lipids themselves are also recognized and endocytized through macrophage receptors. We previously showed that the adduct formed by the ...