DED cell model and rat model were constructed in this study to validate the critical genes and pathways, and it was confirmed that QXEMY alleviated DED by repressing ferroptosis through inhibiting the ...

In this review, we discuss molecular mechanisms that regulates ferroptosis in the heart, including pathways leading to iron overload and lipid peroxidation as well as the roles of key organelles in ...

Deficiency of the frataxin protein can lead to disruption in iron homeostasis and the molecular pathways that affect NRF2 activation and oxidative stress, causing ferroptosis in dorsal root ganglion ...

To model cell conditions at brain tumor inception, we generated genetically engineered murine gliomas, with deletion of p53 alone (p53) or with constitutively active Notch signaling (N1IC), a pathway ...

Together, the findings suggested that 17α-estradiol extensively reshaped the cell populations, cellular communication, neuropeptide secretion, and neural synapse activity in aged hypothalamus, which ...

God's faithfuless/people's unfaithfulness. Who wins (1:2)? God's wrath (2:2), redemption (2:14). Sinful nation (chap. 4). God withdraws (chap. 5). Repent (chap. 6)! The beginning of the Word of the ...

Using a novel stem cell platform, a team of MUSC researchers has identified a pathway that could be targeted by drugs to reduce fat accumulation in patients with a common form of fatty liver ...