Phenotypic plasticity is a cause of glioblastoma therapy failure. We previously showed that suppressing the ...

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

Strengths: Overall, this study presents a thorough analysis of ciliary defects and cell loss in cholinergic neurons throughout the brain in the LRRK2 G2019S knockin mouse model of Parkinson's disease.

9, 2024 — A study has discovered that recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow out of the fibrous scars of malignant predecessors destroyed by ...

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Identification of potent COVID-19 main protease inhibitors by loading of favipiravir on Mg12O12 and Zn12O12 nanoclusters: an in silico strategy for COVID-19 treatment.