We created OPC-specific conditional knockout mice and showed that C1QL1 deficiency reduces the differentiation of OPCs into oligodendrocytes and reduces myelin production during both development ...

However, HCN2 channels were recently shown to regulate the length of myelin segments and oligodendrocyte-specific knockout of HCN2 ... Bill Stallcup), 1:1000 mouse anti-Olig2 (MABN50, Millipore, ...

How oligodendrocytes use fatty acid metabolism as an energy reserve to maintain axonal function and myelin stability when ...

This study uncovers how oligodendroglial lipid metabolism supports myelin homeostasis and axonal function under metabolic stress, crucial for neurodegeneration. By Vijay Kumar MalesuReviewed by Lily ...

BDNF binds with high-affinity on the TrkB neurotrophin receptor and enhances myelination by increasing the density of oligodendrocyte progenitor cells (OPCs) and playing an important role in CNS ...

with a particular focus on the expression and function of ZDHHC9 in myelin-forming oligodendrocytes (OLs). These valuable findings offer insights into ZDHHC9-related X-linked intellectual disability ...

Astrocytes in the brain exhibit significant regional diversity, but the mechanisms controlling their heterogeneity remain ...

To learn more about the lives of oligodendrocytes, Robert Hill, a neurobiologist at Dartmouth College and coauthor on the study, turned to cell death. While Hill and his team have studied ...