[31] MTX was designed to be a close analog of FA and to block the folate-dependent steps in de novo purine and pyrimidine biosynthesis (Figure 1).

Uric acid is a waste product that is produced when the body breaks down purines, which are found in certain foods. When the body is unable to effectively eliminate uric acid, it can build up and ...

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Gout occurs when your body produces extra uric acid. Your body produces extra uric acid when it breaks down purine chemicals found in certain drinks and food. Once broken down, the uric acid ...