uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...

Molecularly we further show that glycolysis shut down in adipocytes resulted in low mTOR and REPTOR activities, and triggered the release of the TNF-α/egr adipokine, and the production of the dilps ...

The sperm epigenome is shaped in a compartment protected by the blood-testes barrier (BTB) known to deteriorate with age. Permeability of the BTB is regulated by the balance of two mTOR complexes in ...

1 Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, United States 2 Department of Neurology, Wake Forest University School of Medicine, ...

Proteotoxic stress impairs cellular homeostasis and underlies the pathogenesis of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). The proteasomal and autophagic ...

Mitochondria and lysosomes play a very important role in maintaining cellular homeostasis, and the dysfunction of these organelles is closely related to many diseases. Recent studies have revealed ...

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