In a groundbreaking development in the field of geroprotection, recent clinical trials and studies identify pentadecanoic acid (C15:0) as a powerful agent in promoting longevity and healthy aging, ...

Together, the findings suggested that 17α-estradiol extensively reshaped the cell populations, cellular communication, neuropeptide secretion, and neural synapse activity in aged hypothalamus, which ...

"This research reveals complex relationships between metabolic states, immune cell functionality, and responses to immunotherapy, and offers a promising pathway toward developing predictive ...

Adipocytes also play a crucial role in the association between ferroptosis and diabetes through several mechanism. Firstly, the inflammatory state observed in adipose tissue in diabetes may inhibit ...

Another study found that liver cancer cell ferroptosis can be induced by suppressing HULC, mediated by the miR-3200-5p/ATF4 axis. This regulatory pathway emerges as a crucial determinant in the ...

To model cell conditions at brain tumor inception, we generated genetically engineered murine gliomas, with deletion of p53 alone (p53) or with constitutively active Notch signaling (N1IC), a pathway ...

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

Research from Radboud university medical center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells. Previously, it was believed that the memory ...

Ferroptosis is related to host anti-intracellular ... “We have proposed a framework encompassing all discovered host immunological pathways, such as TH1, TH2a, TH2b, TH3, TH9, TH17, TH22 ...