1 Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, United States 2 Department of Neurology, Wake Forest University School of Medicine, ...

I really enjoyed the recent article regarding 107-year-old Rheb’s Candies (“Global cocoa shortages could mean more expensive chocolate treats in Baltimore,” Aug. 16). I’m 82 years old and ...

If the hypothesis is supported, then RHEB knockdown should eliminate the cell size effect of Dyrk1a overexpression. We thank the reviewer for suggesting this experiment. We have overexpressed DYRK1A ...

The membrane-associated E3 ubiquitin ligase ZNRF2 is released into the cytosol upon its phosphorylation by Akt. In this study, we show that ZNRF2 interacts with mTOR on membranes, promoting the amino ...