Combination of ERK and autophagy inhibition as a treatment
网页2019年3月4日 · Using several complementary experimental strategies, we determined that, in contrast to increasing autophagy, ERK inhibition impaired other metabolic processes such as glycolysis and...
Autophagy proteins regulate ERK phosphorylation - Nature
网页2013年11月18日 · Autophagy is a conserved pathway that maintains cellular quality control. Extracellular signal-regulated kinase (ERK) controls various aspects of cell physiology including proliferation....
Combination of ERK and autophagy inhibition as a treatment
网页We show that, to our surprise, suppression of KRAS increased autophagic flux, as did pharmacological inhibition of its effector ERK MAPK. Furthermore, we demonstrate that either KRAS suppression or ERK inhibition decreased …
ERK MAPK signaling pathway inhibition as a potential target to …
网页2023年4月5日 · Autophagy, deregulation of intracellular survival pathways and ERK hyperphosphorylation may contribute to SMN-reduced MNs collapse, offering a useful strategy to develop new therapies to...
Inhibition of ERK downregulates autophagy via mitigating …
网页2023年8月14日 · This study aimed to explore the molecular function changes of ERK-Drp1/Mfn2-autophagy signaling pathway in SH-SY5Y cell oxygen-glucose deprivation/reoxygenation (OGD/R) model, to further clarify the pathophysiological mechanism of CIRI, and to provide a new strategy for cerebral protection after CIRI.
Combination Treatment With Inhibitors of ERK and Autophagy …
网页2021年6月29日 · Notably, autophagy inhibition by hydroxychloroquine (HCQ) increases the response of lung cancer cells to BA in combination with ERKi. In vivo, the three-drug combination (BA, ERKi, and HCQ), resulted in superior therapeutic efficacy than single or dual treatments in the xenograft mouse model.
Unraveling the interplay between RAS/RAF/MEK/ERK signaling …
网页2023年11月1日 · The RAS-induced activation of ERK controls the transition from the G1 to the S phase in the cell cycle. Reliable experimental evidence demonstrates that the knockout of three RAS genes or ERK1/2 genes causes the arrest of mouse embryonic fibroblasts (MEFs) in the G1 phase [48].
Autophagy proteins regulate ERK phosphorylation - PubMed
网页Autophagy is a conserved pathway that maintains cellular quality control. Extracellular signal-regulated kinase (ERK) controls various aspects of cell physiology including proliferation. Multiple signalling cascades, including ERK, have been shown to regulate autophagy, however whether autophagy pro ….
Autophagy proteins regulate ERK phosphorylation - PMC
网页Autophagy is a conserved pathway that maintains cellular quality control. Extracellular signal-regulated kinase (ERK) controls various aspects of cell physiology including proliferation. Multiple signalling cascades, including ERK, have been shown to regulate autophagy, however whether autophagy proteins (ATG) regulate cell signalling is …
A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy …
网页Here we report that a non-canonical MEK/ERK module, which is positioned downstream of AMP-activated protein kinase (AMPK) and upstream of tuberous sclerosis complex (TSC), regulates autophagy by regulating Beclin 1. Depletion of ERK partially inhibited autophagy, whereas specific inhibition on MEK completely inhibited autophagy.
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