LILRB4 signalling in leukaemia cells mediates T cell ... - Nature
网页2018年10月17日 · We confirmed specific binding of recombinant APOE to LILRB4 using microscale thermophoresis (MST), surface plasmon resonance (SPR) and bio-layer interferometry (Octet).
Disrupting LILRB4/APOE Interaction by an Efficacious Humanized …
网页Leukocyte immunoglobulin-like receptor B4 (LILRB4), which suppresses T-cell activation and supports tissue infiltration of AML cells, represents an attractive drug target for anti-AML therapeutics. Here, we report the identification and development of an LILRB4-specific humanized mAb that blocks LILRB4 activation.
Antibody-mediated targeting of human microglial leukocyte Ig …
网页2024年4月3日 · Biochemical, site-directed mutagenesis and in silico modeling assays showed that human LILRB4 binds mouse ApoE (mApoE) and that anti-human LILRB4 mAb blocks such interaction, suggesting that ApoE is at …
LilrB3 is a putative cell surface receptor of APOE4
网页2023年1月2日 · Together, our study identifies LilrB3 as a putative immune cell surface receptor for APOE4, but not APOE2, and may have implications for understanding the biological functions as well as disease ...
LILRB4 ITIMs mediate the T cell suppression and infiltration of acute ...
网页2019年11月7日 · We discovered that LILRB4 supports tumor growth by facilitating leukemia cell infiltration into tissues and by suppressing T-cell activity through the apolipoprotein E...
LILRB4 signalling in leukaemia cells mediates T cell ... - PubMed
网页Here we use mouse models and human cells to show that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LILRB4, SHP-2, uPAR and ARG1 in acute myeloid ...
LILRB4, an immune checkpoint on myeloid cells : Blood Science
网页Independent studies have shown that LILRB4 is specifically expressed on monocytic AML cells but not on other subtypes of AML cells. 35,102,103 In AML, apolipoprotein E (APOE) binds to LILRB4, in turn recruiting SHP-2 to the intracellular ITIMs of LILRB4, which further activates the NFκB signaling pathway to promote leukemia cell infiltration ...
LILRB4, an immune checkpoint on myeloid cells - PMC
网页2022年5月17日 · Independent studies have shown that LILRB4 is specifically expressed on monocytic AML cells but not on other subtypes of AML cells. 35,102,103 In AML, apolipoprotein E (APOE) binds to LILRB4, in turn recruiting SHP-2 to the intracellular ITIMs of LILRB4, which further activates the NFκB signaling pathway to …
Antibody-mediated targeting of human microglial leukocyte Ig …
网页2024年4月4日 · Human leukocyte Ig-like receptor B4 (LILRB4) is an inhibitory receptor of the immunoglobulin (Ig) superfamily that is expressed on myeloid cells and recognizes apolipoprotein E (ApoE) among other ligands. Here, we find that LILRB4 is highly expressed in the microglia of patients with AD.
Disrupting LILRB4/APOE Interaction by an Efficacious Humanized …
网页2019年8月1日 · Leukocyte immunoglobulin-like receptor B4 (LILRB4), which suppresses T-cell activation and supports tissue infiltration of AML cells, represents an attractive drug target for anti-AML therapeutics. Here, we report the identification and development of an LILRB4-specific humanized mAb that blocks LILRB4 activation.
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