Targeting mRNA processing as an anticancer strategy
网页2019年9月25日 · Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations, alterations...
mRNA-based therapeutics: powerful and versatile tools to combat ...
网页2022年5月21日 · The development of mRNA-based therapeutics mainly includes mRNA design, synthesis, mRNA entrapment, pharmacodynamics, pharmacokinetics, safety evaluation in vivo and in vitro, manufacturing,...
mRNA nanodelivery systems: targeting strategies and …
网页2023年9月22日 · Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ. In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized.
mRNA vaccines in disease prevention and treatment
网页2023年9月20日 · Several antigens have been used as targets for mRNA vaccine development, such as MAGE-A3, MAGE-A2, gp100, and tyrosinase. MAGE-A3 and MAGE-C2 are exclusively expressed in germ cells and tumor ...
Targeting materials and strategies for RNA delivery - PMC
网页2023年8月21日 · For the purpose of achieving site-specific accumulation of RNA drugs, researchers have scrutinized various physical parameters of non-viral vectors, including protein corona, particle size, surface and vector charge, and particle shape, with the aim of optimizing the potential for targeted delivery of nanoparticles.
Current landscape of mRNA technologies and delivery systems for …
网页2024年9月10日 · Then, we summarize key points pertaining to preclinical and clinical development of mRNA therapeutics. Finally, we cover topics related to targeted delivery systems, including endosomal escape and targeting of immune cells, tumors and organs for use with mRNA vaccines and new treatment modalities for human diseases.
Clinical advances and ongoing trials of mRNA vaccines for cancer ...
网页Years of research exploring mRNA vaccines for cancer treatment in preclinical and clinical trials have set the stage for the rapid development of mRNA vaccines during the COVID-19 pandemic. Therapeutic cancer vaccines based on mRNA are well tolerated, and the inherent advantage in ease of production, which rivals the best available conventional ...
Targeting strategies for mRNA delivery - ScienceDirect
网页2022年6月1日 · Today's leading mRNA vaccines against coronavirus are using lipid nanoparticle (LNP) technology that encodes the viral spike glycoprotein receptor-binding domain as the antigen target. Both LNP mRNA vaccines, Moderna developed the mRNA-1273 vaccine (NCT04470427) and Pfizer/BioNTech also developed BNT162b1 and BNT162b2 (NCT04368728) vaccine that ...
mRNA Targeting, Transport and Local Translation in Eukaryotic Cells ...
网页Here we review the current concepts of the molecular mechanisms of transport, selective localization and local translation of cellular and viral mRNAs, their effects on protein targeting and topogenesis, and on the regulation of protein biosynthesis in different compartments of the eukaryotic cell.
Small RNA Targets: Advances in Prediction Tools and High …
网页2022年12月11日 · Through the mediation of proteins from the Argonaute family, miRNAs target messenger RNAs (mRNAs) for destruction (cleavage or repression). Other types of sRNAs, including transfer-RNA-derived fragments (tRFs) and small interfering RNAs (siRNAs), have been indicated as potential regulators of gene expression.
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