Targeting mTOR signaling overcomes acquired resistance to …
网页2021年7月24日 · Combining western blotting, immunohistochemistry, and reverse phase protein array (RPPA), we aim to understanding the role of the mTORC1 signaling pathway, a center node of intracellular...
mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs …
网页2019年12月27日 · In a cell culture model for osteoblastic differentiation of pluripotent human MSC we found distinct roles for mTORC1 and mTORC2 in the regulation of differentiation towards calcifying osteoblasts...
mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling …
网页2020年12月28日 · Emerging evidence points to mTORC1 signaling as a critical regulator of cardiovascular function with implications for cardiovascular disease. Here, we show that selective disruption of mTORC1, through conditional Raptor gene deletion, in endothelial or smooth muscle cells alter vascular function.
mTORC1 Mediates Biphasic Mechano‐Response to Orchestrate …
网页2023年12月2日 · The mechanistic target of rapamycin complex 1 (mTORC1) is a central pillar in metabolic regulation in response to both intra- and extra-cellular signals. [12-18] Its activation associates with enhanced protein translation [19, 20] and decreased autophagy. [21, 22] mTORC1 is recruited to the lysosomal surface to release its
Amino acid-dependent control of mTORC1 signaling: a variety of ...
网页2020年8月17日 · mTORC1 regulates cell growth and metabolism by modulating protein, lipid, and purine synthesis, as well as lysosome biogenesis and autophagy (Fig. 1 b). mTORC1 activity is influenced by a variety of signals such as amino acids, glucose, growth factors, energy levels, and stresses [2, 12, 13, 14, 15, 16, 17, 18].
mTORC1-selective activation of translation elongation promotes …
网页2023年9月29日 · Targeted deletion of Raptor, a component of mechanistic target of rapamycin complex 1 (mTORC1), reveals an essential role for mTORC1 in initiation/maintenance of leukemia...
Enhanced mTORC1 signaling and protein synthesis in pathologic …
网页2023年11月29日 · Pathologic α-synuclein was found to bind with the tuberous sclerosis protein 2 (TSC2) and to trigger the activation of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1), which augmented mRNA translation and protein synthesis, leading to neurodegeneration.
mTORC1 Controls Mitochondrial Activity and Biogenesis
网页In this study, we demonstrate that mTORC1 stimulates mitochondrial biogenesis and activity, thereby bolstering ATP production capacity. mTOR inhibitors caused a decrease in ATP levels associated with impaired mitochondrial function and glycolysis.
Western Diet-Mediated mTORC1-Signaling in Acne, Psoriasis, …
网页2012年10月28日 · The presented comprehensive concept of Western diet-induced hyperactive mTORC1 signaling explains the attenuating effects of natural plant-derived mTORC1 inhibitors on mTORC1 signaling. These compounds have been created in the course of evolution to antagonize metabolic activity of mTORC1-sensitive plant invaders.
Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser
网页The rapamycin-sensitive mTOR complex 1 (mTORC1) promotes protein synthesis, cell growth, and cell proliferation in response to growth factors and nutritional cues. To elucidate the poorly defined mechanisms underlying mTORC1 regulation, we have studied the phosphorylation of raptor, an mTOR-interacting partner.