Glutamate receptor - Wikipedia
网页Glutamate receptors serve to facilitate the impact of the neurotransmitter glutamate in the central nervous system. These receptors are pivotal in excitatory synaptic transmission, synaptic plasticity, and neuronal development. They are vital for functions like learning, memory, and neuronal communication. [13]
Biochemistry, Glutamate - StatPearls - NCBI Bookshelf
网页2022年12月19日 · Glutamate acts on several types of receptors, including excitatory amino acid transporters (EAATs 1-5), vesicular glutamate transporters (VGLUTs), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors, N-Methyl-D-aspartate (NMDA) receptors, glutamine-cystine exchangers (xCT), and …
Structure, Function, and Pharmacology of Glutamate Receptor …
网页Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs). These ligand-gated ion channels are critical to brain function and are centrally implicated in numerous psych ….
Glutamate as a Neurotransmitter in the Brain: Review of …
网页Glutamate is the principal excitatory neurotransmitter in brain. Our knowledge of the glutamatergic synapse has advanced enormously in the last 10 years, primarily through application of molecular biological techniques to the …
2 Overview of the Glutamatergic System - National Center for ...
网页Glutamate is the major excitatory neurotransmitter in the nervous system. Glutamate pathways are linked to many other neurotransmitter pathways, and glutamate receptors are found throughout the brain and spinal cord in neurons and glia. As an amino acid and neurotransmitter, glutamate has a large array of normal physiological functions.
Glutamate Receptors - Neuroscience - NCBI Bookshelf
网页These glutamate receptors are named after the agonists that activate them: NMDA (N -methyl- D -aspartate), AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate), and kainic acid. All of the ionotropic glutamate receptors are nonselective cation channels, allowing the passage of Na + and K +, and in some cases small amounts of Ca 2+.
Glutamate, glutamate receptors, and downstream signaling pathways
网页2013年9月22日 · Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in biosynthetic, bioenergetic, metabolic, and oncogenic signaling pathways. Glutamate signaling activates a family of rec ….
Frontiers | Glutamate: The Master Neurotransmitter and Its …
网页2021年10月28日 · Glutamate is an excitatory neurotransmitter with several types of receptors found throughout the central nervous system, and its metabolism is important to maintaining optimal levels within the extracellular space. As such, it is important to memory, cognition, and mood regulation.
Glutamatergic Signaling in the Central Nervous System ... - PubMed
网页2018年6月27日 · Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as a key neuromodulator to control synapse and circuit function over a wide range of spatial and temporal scales. This functional diversity is decoded by two receptor families: ionotropic glutamate receptors …
Glutamate Receptor - an overview | ScienceDirect Topics
网页Glutamate receptors (GluRs) comprise ionotropic receptors (iGluRs), which are tetrameric ion channels, and metabotropic receptors (mGluRs), which are class C dimeric G-protein coupled receptors (GPCRs). The iGluRs consist of three classes of receptors: NMDARs, AMPARs, and kainateRs.
跳至内容