Kinetochore structure and function: Trends in Cell Biology
网页Kinetochore structure and function. The vertebrate kinetochore is a complex structure that specifies the attachments between the chromosomes and microtubules of the spindle and is thus essential for accurate chromosome segregation. Kinetochores are assembled on centromeric chromatin through complex pathways that are coordinated with the cell cycle.
A Molecular View of Kinetochore Assembly and Function
网页2017年1月24日 · In eukaryotes, the kinetochore is a proteinaceous multi-subunit assembly whose main function is to generate load-bearing attachments of sister chromatids (the replicated chromosomes held together by the protein complex cohesin) to spindle microtubules during cell division (mitosis or meiosis) (Figure 1 A).
Molecular architecture of the kinetochore–microtubule interface
网页The kinetochore is composed of a number of conserved protein complexes that direct its specification and assembly, bind to spindle microtubules and regulate chromosome segregation.
Kinetochores: Current Biology - Cell Press
网页2000年7月15日 · Probably the most commonsensical definition describes the kinetochore as the protein machine that assembles on centromeric DNA during mitosis/meiosis. What about the DNA sequences on which kinetochores assemble?
Dynamics of kinetochore structure and its regulations during …
网页2020年2月12日 · The kinetochore is a structural interface for the microtubule attachment and provides molecular surveillance mechanisms that monitor and ensure the precise microtubule attachment as well, including …
Kinetochore Function from the Bottom Up - Cell Press
网页Biochemical reconstitution of kinetochore activities has shown how a catch-bond connection is established and maintained, how kinetochore proteins assemble onto a CENP-A nucleosome template, and how individual subcomplexes come together to mediate centromere–microtubule connections.
A blueprint for kinetochores — new insights into the ... - Nature
网页2011年6月2日 · The kinetochore is a large complex of proteins that physically links centromeric DNA to microtubules. Recent research has identified the individual kinetochore building blocks and studied how...
Kinetochore assembly and function through the cell cycle
网页2016年7月6日 · The kinetochore is an essential structure for the chromosome segregation machinery in eukaryotes; it serves as a bridge between the spindle microtubules and chromosomes.
An updated view of the kinetochore architecture - PubMed
网页The kinetochore is a supramolecular complex that facilitates faithful chromosome segregation by bridging the centromere and spindle microtubules.
Kinetochore Moves Ahead: Contributions of Molecular and …
网页2009年12月1日 · The kinetochore is both the anchor to the mitotic spindle for chromosomes at division and the motor for distribution of chromosomal units to daughter cells. In addition, the kinetochore plays a key role in …
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