CD74 - Wikipedia
网页HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene.
CD74 Gene - GeneCards | HG2A Protein | HG2A Antibody
网页2024年8月5日 · GeneCards Summary for CD74 Gene. CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Nasal Cavity Lymphoma and O'nyong'nyong Fever. Among its related pathways are Innate Immune System and Immune response Antigen presentation by MHC class II.
The biological function and significance of CD74 in immune ... - PubMed
网页CD74 plays important roles in many inflammatory diseases, such as liver fibrosis, type I diabetes, systemic lupus erythematosus, and Alzheimer disease. In this study, we will focus on the immunological functions of CD74 molecules and …
CD74 supports accumulation and function of regulatory T cells
网页2024年5月3日 · Using available transcriptomic data from single-cell RNA and bulk RNA sequencing from CD4+ T cells from cancer patients, we identified the cluster of differentiation 74 (CD74) to be a specific...
CD74 as a prognostic and M1 macrophage infiltration marker in a ...
网页2024年4月7日 · CD74 is involved in cancer immune pathways in BRCA. CD74 functions in tumorigenesis and their underlying mechanisms were further investigated.
The role of CD74 in cardiovascular disease - PMC - National …
网页2023年1月12日 · Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular chaperone of major histocompatibility complex class II (MHC II) molecules involved in antigen presentation. CD74 has recently been shown to be a receptor for the macrophage migration inhibitory factor family proteins (MIF/MIF2).
CD74: an emerging opportunity as a therapeutic target in ... - PubMed
网页The role of CD74 signaling in inflammatory and carcinogenic processes is outlined as is the use of CD74 as a therapeutic target (in cancer) and tool (as a vaccine). Expert opinion: CD74 has several roles within the cell and throughout the immune system.
The biological function and significance of CD74 in immune diseases
网页2016年10月17日 · CD74 plays important roles in many inflammatory diseases, such as liver fibrosis, type I diabetes, systemic lupus erythematosus, and Alzheimer disease. In this study, we will focus on the immunological functions of CD74 molecules and its roles in immune-relevant disorders.
972 - Gene ResultCD74 CD74 molecule [ (human)] - National …
网页2024年8月27日 · CD74 represents a novel and promising target for treatment of multiple myeloma. its cytoplasmic tail regulates endosome fusion and morphology; CD74 is expressed on the surface of gastric cells, and Helicobacter pylori can use this receptor as a point of attachment to gastric epithelial cells, which lead to IL-8 production.
MIF-CD74 signaling impedes microglial M1 polarization and facilitates ...
网页2016年5月9日 · We show that MIF-CD74 signaling inhibits interferon (IFN)-γ secretion in microglia through phosphorylation of microglial ERK1/2 (extracellular signal-regulated protein kinases 1 and 2).
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