An Overview of Targeted Alpha Therapy with 225Actinium and …
网页The predominant decay path of 225 Ac yields net four alpha particles with energies ranging from 5.8 to 8.4 MeV and associated tissue ranges of 47 to 85 µm [1]. In addition, the cascade includes two beta disintegrations of 1.6 and 0.6 MeV maximum energy.
Actinium-225 in targeted alpha-particle therapeutic applications
网页The results indicated that there was a distinct advantage in using a parent radionuclide such as 225 Ac, having a 10 d half-life and yielding 4 alpha particles per decay. Lower normal tissue doses resulted for a given tumor dose in comparison to those radionuclides yielding fewer alpha particles.
Actinium-225 for Targeted α Therapy: Coordination Chemistry …
网页2018年10月10日 · The α-emitting radionuclide actinium-225 possesses nuclear properties that are highly promising for use in targeted α therapy (TAT), a therapeutic strategy that employs α particle emissions to destroy tumors.
Actinium chelation and crystallization in a macromolecular …
网页2024年7月15日 · Targeted alpha therapy (TAT) pairs the specificity of antigen targeting with the lethality of alpha particles to eradicate cancerous cells. Actinium-225 [225Ac; t1/2 = 9.920 (3) days] is an...
Actinium-225 Targeted Agents: Where Are We Now?
网页2023年11月1日 · Over the last decade, the physical and chemical attributes of Actinium-225 (225 Ac) including its half-life, decay schemes, path length, and straightforward chelation ability has peaked interest for brachytherapy agent development.
Actinium-225-PSMA radioligand therapy of metastatic castration ...
网页2024年1月10日 · Actinium-225 (225 Ac)-PSMA RLT uses the alpha emitter 225 Ac to potentially improve the treatment effect of PSMA-targeted RLT. 225 Ac emits several alpha particles in its decay scheme that are much more energetic than the …
Feasibility of a novel photoproduction of 225Ac and 227Th with …
网页2022年1月10日 · We propose an innovative way to produce both 225 Ac and 227 Th, two precious radioisotopes enabling promising targeted alpha therapy, in a natural thorium target bombarded with a 30–90 MeV...
H2BZmacropa-NCS: A Bifunctional Chelator for Actinium-225 …
网页2022年6月7日 · Actinium-225 (225 Ac) is one of the most promising radionuclides for targeted alpha therapy (TAT). With a half-life of 9.92 days and a decay chain that emits four high-energy α particles, 225 Ac is well-suited for TAT when conjugated to macromolecular targeting vectors that exhibit extended in vivo circulation times.
Actinium-225 - Wikipedia
网页Actinium-225 (225Ac, Ac-225) is an isotope of actinium. It undergoes alpha decay to francium-221 with a half-life of 10 days, and is an intermediate decay product in the neptunium series (the decay chain starting at 237 Np). Except for minuscule quantities arising from this decay chain in nature, 225 Ac is entirely synthetic.
The Journey of Actinium-225: How Scientists Discovered a New …
网页Actinium-225 has such promise because it's an alpha emitter. Alpha emitters discharge alpha particles, which are two protons and two neutrons bound together. As alpha particles leave an atom, they deposit energy along their short path.