Apolipoprotein E: Structure and Function in Lipid Metabolism ...
网页Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis.
Apolipoprotein E: structure and function in lipid metabolism ... - PubMed
网页Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis. A major function of apoE is to mediate the binding …
Apolipoprotein E: Structural Insights and Links to Alzheimer …
网页2021年1月20日 · In this review, we discuss the historical progress in understanding ApoE structure and how these insights can be used to better understand AD neuropathology and pathogenesis. We will also discuss new directions that will be necessary to further advance our understanding of ApoE structure/function relationships.
Apolipoprotein E in Alzheimer’s disease trajectories and the next ...
网页2024年6月19日 · Structure and function of ApoE. Human ApoE is a glycoprotein of 299 amino acids occupying the surface of specific lipoprotein particles, where it binds to cholesterol and phospholipids (Fig....
Apolipoprotein E structure: insights into function - PubMed
网页Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins. Through its interaction with members of the low-density lipoprotein receptor family, apoE has a key role in lipid transport both in the plasma and in the central nervous system. Its three common structural isoforms differentially affect the risk of developing ...
Apolipoprotein E: structure determines function, from …
网页Apolipoprotein (apo) E has roles beyond lipoprotein metabolism. The detrimental effects of apoE4 in cardiovascular, neurological, and infectious diseases correlate with its structural features (e.g., domain interaction) that distinguish it from apoE3 and apoE2. Structure/function studies revealed that apoE2 is severely defective in LDL receptor ...
Apolipoprotein E structure: insights into function: Trends in ...
网页ApoE contains 299 residues (relative molecular mass = 34 000) and was originally identified as a main component of lipoproteins in plasma. Similar to other soluble apolipoproteins, apoE contains amphipathic α-helical lipid-binding domains that enable it to switch reversibly between a lipoprotein-bound and a lipid-free state.
Concerning the structure of apoE - PMC - National Center for ...
网页2013年10月1日 · Apolipoprotein E (apoE), first described in 1973, is a truly fascinating protein. While studies initially focused on its role in cholesterol and lipid metabolism, one apoE isoform (apoE4) is a major risk factor for development of late onset Alzheimer's disease. Yet the difference between apoE3, the common form, and apoE4 is a …
Apolipoprotein E and Alzheimer disease: pathobiology and …
网页2019年7月31日 · Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2...
The cell biology of APOE in the brain - ScienceDirect
网页2024年4月1日 · Structure of APOE. APOE is a 34-kDa protein consisting of 299 amino acids preceded by an 18 amino acid N-terminal endoplasmic reticulum (ER) signal peptide [15, 16]. APOE consists of two domains, an N-terminal domain making up residues 1–167 and a C-terminal domain from residues 206–299 …
- 某些结果已被删除