Autophagy in kidney homeostasis and disease - Nature
网页2020年7月23日 · Autophagy is a lysosomal degradation pathway that breaks down cytoplasmic components for clearance and reuse. Depending on the type of cargo to be degraded and the route of cargo delivery to...
Autophagy in Chronic Kidney Diseases - PMC - National Center …
网页2019年1月16日 · Abnormal autophagy function can induce loss of podocytes, damage proximal tubular cells, and glomerulosclerosis. After acute kidney injuries, activated autophagy protects tubular cells from apoptosis and enhances cellular regeneration. Patients with chronic kidney diseases have impaired autophagy that …
Autophagy in kidney homeostasis and disease - PubMed
网页Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic components. Basal autophagy in kidney cells is essential for the maintenance of kidney homeostasis, structure and function. Under stress conditions, autophagy is altered as part of the adaptive response of kidney cells, in ….
Autophagy in kidney homeostasis and disease - PMC - National …
网页In this Review, we provide an overview of the cellular and molecular basics of autophagy, analyse the physiological roles of basal autophagy in the major types of resident kidney cells and summarize current evidence on the regulation and pathological roles of autophagy in glomerular and tubulointerstitial diseases.
Autophagy in Chronic Kidney Diseases - PubMed
网页2019年1月16日 · Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney ….
网页2020年7月23日 · Autophagy is a lysosomal degradation pathway that breaks down cytoplasmic components for clearance and reuse. Depending on the type of cargo to be degraded and the route of cargo delivery to...
Autophagy Function and Regulation in Kidney Disease
网页2020年1月7日 · Autophagy is a dynamic process by which intracellular damaged macromolecules and organelles are degraded and recycled for the synthesis of new cellular components. Basal autophagy in the kidney acts as a quality control system and is vital for cellular metabolic and organelle homeostasis.
Autophagy in Kidney Disease - PubMed
网页2020年2月10日 · Autophagy has been implicated in acute kidney injury, which can arise in response to nephrotoxins, sepsis, and ischemia/reperfusion, and in chronic kidney diseases. The latter includes comorbidities of diabetes and recent evidence for chronic obstructive pulmonary disease-associated kidney injury.
Autophagy in kidney disease: Advances and therapeutic potential ...
网页2020年1月1日 · Autophagy exerts important functions in acute kidney injury (AKI). Schema showing the role of autophagy during sepsis, ischemia-reperfusion injury (IRI), cisplatin, and heavy-metal-induced AKI. The model-specific functions of …
Autophagy in kidney disease: Advances and therapeutic potential ...
网页2020年1月1日 · Autophagy plays a critical role in maintaining the morphology and viability of various cells in the kidney and their homeostasis during both healthy and diseased conditions.1, 2 The autophagy-dependent recycling of damaged or superfluous organelles and elimination of oxidative stress is particularly …
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