Coenzyme A biosynthesis: mechanisms of regulation, function
网页2024年6月13日 · Here, we discuss the many cellular roles of CoA and the regulatory mechanisms that govern its biosynthesis from cysteine, ATP and the essential nutrient pantothenate (vitamin B 5), or from...
Biosynthesis of Pantothenic Acid and Coenzyme A - PubMed
网页Pantothenate is vitamin B5 and is the key precursor for the biosynthesis of coenzyme A (CoA), a universal and essential cofactor involved in a myriad of metabolic reactions, including the synthesis of phospholipids, the synthesis and degradation of fatty acids, and the operation of the tricarboxylic acid cycle.
Biosynthesis of Pantothenic Acid and Coenzyme A - PMC
网页The CoA biosynthetic pathway is a popular target for development of novel antibacterial agents, due to the distinctive differences between the bacterial and the mammalian proteins that catalyze the PanK reaction, and the phosphopantetheine adenylyltransferase (PPAT) …
Constructing a synthetic pathway for acetyl-coenzyme A from ... - Nature
网页2019年3月26日 · Acetyl-CoA is a fundamental metabolite for all life on Earth, and is also a key starting point for the biosynthesis of a variety of industrial chemicals and natural products. Here we design and...
Jump-starting CoA biosynthesis | Nature Chemical Biology
网页2015年9月17日 · Coenzyme A (CoA) acts as the universal acyl carrier in metabolism, either directly or by providing the 4′-phosphopantetheine moiety of acyl and peptidyl carrier proteins 1,2.
The Pathophysiological Role of CoA - PMC - National Center for ...
网页2020年11月28日 · This review summarizes current knowledge of CoA-SH subcellular concentrations, the roles of CoA-SH synthesis and degradation processes and changes in the level of CoA-SH under pathological conditions, such as neurodegenerative diseases, cancer, myopathies, infectious diseases and the genetic make-up of CoA-SH genes.
Regulation of the CoA Biosynthetic Complex Assembly in …
网页2021年1月24日 · The biosynthesis of CoA is regulated at multiple levels. The enzymatic feedback mechanism is the main point of regulation and involves the inhibition of Pank, the first rate-limiting enzyme in CoA biosynthesis, by acetyl-CoA, a potent allosteric inhibitor of all four mammalian Pank isoforms .
IJMS | Free Full-Text | Regulation of the CoA Biosynthetic Complex ...
网页2021年1月24日 · The biosynthesis of CoA is regulated at multiple levels. The enzymatic feedback mechanism is the main point of regulation and involves the inhibition of Pank, the first rate-limiting enzyme in CoA biosynthesis, by acetyl-CoA, a potent allosteric inhibitor of all four mammalian Pank isoforms .
Coenzyme A Biosynthesis: Reconstruction of the Pathway in …
网页2004年7月1日 · Starting from the known E. coli and human enzymes required for the biosynthesis of CoA, phylogenetic profiles and chromosomal proximity methods enabled an almost complete reconstruction of archaeal CoA biosynthesis. This includes the identification of strong candidates for archaeal pantothenate synthetase and pantothenate kinase, which are ...
Regulation of the CoA Biosynthetic Complex Assembly in
网页2021年1月24日 · In this study, we report the assembly of all five enzymes that drive CoA biosynthesis, in HEK293/Pank1β and A549 cells, using the in situ proximity ligation assay. Furthermore, we show that the association of CoA biosynthetic enzymes is strongly upregulated in response to serum starvation and oxidative stress, whereas insulin and growth factor ...
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