The oligodendrocyte-specific antibody 'CC1' binds Quaking 7
网页We show that the CC1 antibody binds Quaking 7, an RNA-binding protein that is highly up-regulated in myelinating oligodendrocytes in the central nervous system. The monoclonal antibody anti-adenomatous polyposis coli (APC) clone CC1, is the antibody most commonly used to specifically label the cell bodies of mature oligodendrocytes.
Astrocyte-oligodendrocyte interaction regulates central ... - Nature
网页2023年6月8日 · Luteolin treatment of GFAP-Nrf2 mice restored numbers of oligodendrocyte lineage cells (Olig2+; Fig. 7i, j) and mature oligodendrocytes (CC1+Olig2+; Fig. 7i, k), increased the proportion of...
Overcoming the inhibitory microenvironment surrounding oligodendrocyte …
网页2021年3月26日 · Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed...
Pervasive environmental chemicals impair oligodendrocyte
网页2024年3月25日 · Quaternary compounds, ubiquitous in disinfecting agents and personal care products, were potently and selectively cytotoxic to developing oligodendrocytes, whereas organophosphate flame retardants,...
Oligodendrocyte Lineage Marker Expression in eGFP-GFAP
网页2020年12月21日 · To verify that the applied anti-CC1 antibody reliably detects cells of the oligodendrocyte lineage, we processed brain sections from control and cuprizone-intoxicated wild-type mice for anti-OLIG2/anti-CC1 immunofluorescence double-staining, and quantified the co-localization of both signals.
The Oligodendrocyte-Specific Antibody “CC1” Binds Quaking 7
网页2016年7月1日 · The mouse monoclonal antibody marketed as anti‐adenomatous polyposis coli clone CC 1, often referred to as CC 1, is the antibody most commonly used to specifically...
A Guide to Oligodendrocyte Markers - Biocompare
网页2022年10月12日 · Premyelinating and myelinating oligodendrocytes can be identified using the CC1 antibody. However, MYRF labeling may be better for counting oligodendrocyte numbers, given its better specificity and nuclear localization. (CC1 also labels other progenitors in the developing CNS.)
Oligodendrocytes in human induced pluripotent stem cell-derived ...
网页2023年8月8日 · Here, we demonstrate the in vitro and in vivo production of myelinating oligodendrocytes from a human induced pluripotent stem cell (iPSC)-derived long-term neuroepithelial stem (lt-NES) cell line, which also gives rise to neurons with the capacity to integrate into stroke-injured, adult rat cortical networks.
Gene expression in oligodendrocytes during remyelination …
网页2019年5月5日 · Double immunolabeling showed abundant colocalization of HA with the immature/mature oligodendrocyte marker CC1, as well as some colocalization of HA with GSTπ. Lack of colocalization was observed with other cell-specific markers, namely GFAP for astrocytes, NF200 for neurons, and Iba1 for microglia ( Fig. 2 B and D ).
Region-specific distribution of Olig2-expressing astrocytes in adult ...
网页2021年2月17日 · Unlike myelin protein CNPase, CC1 was highly localized in the soma of the oligodendrocytes (Fig. 3). Our data showed that a majority of CC1 + cells (red) were co-stained with Olig2 (green) throughout the brain (91.0% ~ 99.6%, white arrowheads, Fig. 3b, d–m) and spinal cord (98.70%, white arrowheads, Fig. 3n).