CD38, a Receptor with Multifunctional Activities: From Modulatory ...
网页2019年11月27日 · Recently, several studies reported CD38 as a part of ecto-enzymatic networks that generate adenosine (ADO) from different substrates, including ATP and NAD +. The “canonical” pathway for ADO production is composed of CD39 (NTP diphosphohydrolase) that converts ATP to ADP and AMP, and CD73 (ecto-5′-nucleotidase) that converts AMP to ADO ...
CD38: A Significant Regulator of Macrophage Function
网页2022年2月17日 · Cluster of differentiation 38 (CD38) is a cell surface glycoprotein and multifunctional extracellular enzyme. As a NADase, CD38 produces adenosine through the adenosine energy pathway to cause immunosuppression. As a cell surface receptor, CD38 is necessary for immune cell activation and proliferation. The aggregation and polarization of ...
CD38 is involved in cell energy metabolism via activating the ... - PubMed
网页Further experiments using an ATP test kit and lactate test kit revealed that CD38 promotes glucose consumption, increases lactate accumulation and increases ATP production. In addition, CD38 increases the phosphorylation of phosphatidylserine/threonine kinase (AKT), mechanistic target of rapamycin (mTOR) and phosphatidylinositol‑4,5 ...
The Good, the Bad and the Unknown of CD38 in the Metabolic ...
网页2019年12月24日 · CD38 can also catalyze the cyclization of NAD to produce cADPR through its ADP ribose cyclase activity, though this function may be secondary to its function as a NADase.
CD38: An important regulator of T cell function - PubMed
网页In this paper, we reviewed the role and mechanism of CD38 + CD4 + T cells / CD38 + CD8 + T cells in cellular immunity and the effects of the CD38-NAD + axis on T cell activity. We also summarized the relationship between the CD38 expression level on T cell surface and disease prediction and prognosis, the effects of anti-CD38 monoclonal ...
Frontiers | The Multi-faceted Ecto-enzyme CD38: Roles in ...
网页In addition to the NAD + glycohydrolase activity, CD38 exhibits inefficient ADP-ribosyl cyclase activity and mediates a base-exchange of vitamin B3 bases in the presence of excess nicotinamide analogs. Another role for CD38 is the regulation of extracellular adenosine, which requires consumption of NAD +.
An NAD + -dependent metabolic checkpoint regulates ... - Nature
网页2024年7月23日 · Here, we show that CD38, an NAD+-dependent metabolic enzyme, promotes HSC proliferation by inducing mitochondrial Ca2+ influx and mitochondrial metabolism in young mice.
Evolving roles of CD38 metabolism in solid tumour …
网页2022年7月11日 · At the biochemical level, CD38 increased the concentration of ATP, lactic acid, cyclic adenosine monophosphate (cAMP), and ADP/acrp30 in malignant tumour cells.
CD38 symmetric dimethyl site R58 promotes malignant tumor cell …
网页3 天之前 · Specifically, CD38 promotes cell proliferation, facilitates the transition of NPC cells from G0-G1 to S phase, and influences intracellular concentrations of key metabolites such as ATP, lactate, and cyclic adenosine monophosphate (cAMP) in NPC cells.
CD38 in Adenosinergic Pathways and Metabolic Re-programming …
网页2019年4月23日 · CD38, a multifunctional protein that acts as both receptor and ectoenzyme, is overexpressed at all stages of myeloma. At neutral and acidic pH, CD38 catalyzes the extracellular conversion of NAD + to regulators of calcium signaling.
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