学懂通路第三期： MAPK信号通路 - 知乎 - 知乎专栏
网页促分裂素原活化蛋白激酶 (mitogen-activated protein kinases, MAPK)信号通路是真核生物信号传递网络中的重要途径之一，是细胞增殖、分化、细胞凋亡以及正常条件和病理条件下应激反应的关键信号通路。. MAPK 是一组进化保守的丝氨酸-苏氨酸激酶，可分为4个亚 …
Paeoniflorin attenuates monocrotaline-induced pulmonary arterial ...
网页2022年3月28日 · Either preventive or therapeutic administration of PF could alleviate MCT-induced PAH by attenuating vascular remodeling, alleviating inflammation and EndMT in lung. The underlying mechanism of PF is associated with the inhibition of TAK1-MAPK/NF-κB pathways, which may be promising targets for the therapeutic intervention of PAH.
Cellular mechanosignaling in pulmonary arterial hypertension
网页2021年9月2日 · We developed a computational model of PAAFs mechanosignaling that included TGFβ, MAPK, PDGF, tumor necrosis factor α (TNFα), hypoxia, fibroblast growth factor (FGF), angiotensin II, and Hippo signaling pathways, which are upregulated by PAH, and phenotypic outputs to investigate mechanical regulation of fibrosis in …
BMPR-II deficiency elicits pro-proliferative and anti-apoptotic ...
网页2012年3月2日 · Using mouse primary PASMCs derived from knock-in mice, we demonstrated that BMPR-II dysfunction promotes the activation of small mothers against decapentaplegia-independent mitogen-activated protein kinase (MAPK) pathways via TGFβ-associated kinase 1 (TAK1), resulting in a pro-proliferative and anti-apoptotic response.
A Comprehensive Review on MAPK: A Promising Therapeutic …
网页2019年10月22日 · The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and epigenetic changes.
Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK …
网页2023年3月13日 · In this study, we demonstrated that circ-Ntrk2 expression is upregulated in hypoxic lung tissues and PASMCs and that its deficiency could improve pulmonary vascular remodelling and relieve PAH via the miR-296-5p/TGF-β1/p38 MAPK signal transduction axis, thus establishing potential targets for PAH …
Prostacyclin receptor agonists induce DUSP1 to inhibit ... - PubMed
网页2023年2月15日 · Activated p38 MAPK induces DUSP1 expression, forming a negative feedback loop. Prostacyclin IP receptor agonists (prostacyclin and selexipag) are used to treat PAH. In this study, we aimed to verify whether IP receptor agonists affect DUSP1 expression and accelerate the proliferation of PA-SMCs.
Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of …
网页2013年11月15日 · Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK
Nanomolar levels of PAHs in extracts from urban air induce MAPK ...
网页2014年8月17日 · Our results show that nanomolar concentrations of PAH extracts more strongly activate MAPK signaling and proteins of the AP-1 transcription factor than BP alone suggesting effects due to interactions and that this activation is …
网页The p38 MAPK pathway plays a pivotal role in numer- ous cellular functions. 24,25 Elevated p38 MAPK activity con- tributes to hypoxia-induced pulmonary artery fibroblast