Myelin-associated oligodendrocytic basic protein-dependent myelin …
WEBOct 17, 2023 · The most affected myelin protein encoding genes included myelin basic protein (Mbp), myelin proteolipid protein (Plp), and Mobp (Figs. 1B–I and S1, S2), corroborating previous findings that...
Oligodendrocytes in Development, Myelin Generation and Beyond
WEBNov 12, 2019 · Oligodendrocytes are fundamental to myelin formation in the developing CNS and critical for myelin regeneration following injury including in the most common demyelinating disease multiple sclerosis (MS) [2,3]. In this review, we discuss the journey of oligodendrocytes in development from the embryonic stage to oligodendrocyte function in ...
Oligodendrocyte: Structure, Function and Pathology
WEBApr 10, 2022 · Three integral myelin proteins, myelin basic protein (MBP), 2′-3′cyclic nucleotide-3 phosphodiesterase (CNP ) and proteolipid protein (PLP ), play significant roles in the myelin architecture. MBP is essential for the compaction of two cytoplasmic interfaces of myelin lamellae and formation of major dense line (Wolf et al. 2021 ).
A Glance at the Molecules That Regulate Oligodendrocyte …
WEBMay 15, 2022 · Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. After demyelination occurs because of pathophysiology, remyelination makes repairs similar to myelination.
Single-molecule tracking of myelin basic protein during oligodendrocyte …
WEBNov 20, 2023 · This study aimed to expand our understanding of myelin basic protein (MBP), a key component of central nervous system myelin, by developing a protocol to track and quantifying individual MBP particles during oligodendrocyte (OL) differentiation. MBP particle directionality, confinement, and diffusion were …
Myelin basic protein functions as a microtubule stabilizing ... - PubMed
WEBAug 15, 2006 · Myelin basic protein (MBP) is an oligodendrocyte-specific protein essential for oligodendrocyte morphogenesis at late stages of cell differentiation. There is evidence that the morphogenetic function of MBP is …
Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte …
WEBIt causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain ...
New myelin for old oligodendrocytes | Nature Neuroscience
WEBApr 5, 2022 · Analysis of the proteome of the optic nerve of these mice revealed that Mbp ablation leads to progressively decreased expression of myelin proteins and proteins involved in axon–myelin ...
White matter integrity in mice requires continuous myelin
WEBMar 4, 2022 · Here, we study the integrity of myelinated tracts after experimentally preventing the formation of new myelin in the CNS of adult mice, using an inducible Mbp null allele. Oligodendrocytes...
Dynamics of Oligodendrocyte Generation and Myelination in …
WEBNov 6, 2014 · Oligodendrocytes wrap layers of specialized cell membrane around nerve fibers to form myelin, which provides electrical insulation to increase axonal conduction velocity and the speed of neural processing. Myelination is a largely postnatal process and it continues well into adulthood in humans.
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