Prenylation - Wikipedia
网页Prenylation (also known as isoprenylation or lipidation) is the addition of hydrophobic molecules to a protein or a biomolecule. It is usually assumed that prenyl groups (3-methylbut-2-en-1-yl) facilitate attachment to cell membranes, similar to lipid anchors like the GPI anchor, though direct evidence
Prenylation of aromatic amino acids and plant phenolics by an …
网页2024年7月18日 · Our study demonstrates the potential of RePT as a biocatalyst for the production of bioactive prenylated aromatic amino acids, stilbenes, and various phenolic compounds. • RePT catalyzes prenylation of diverse aromatic substrates. • RePT enables O-prenylation of phenolics, especially stilbenes.
Protein prenylation: unique fats make their mark on biology
网页2016年1月21日 · Structure–function studies of mammalian and yeast ICMT have provided some insights into its orientation within the ER membrane and have identified amino acids that are crucial for its catalytic...
Protein Prenylation and Their Applications | IntechOpen
网页2022年1月10日 · Prenylation is a universal covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. Prenyl group is important for protein-protein binding through specialized prenyl-binding domains.
Prenylation - an overview | ScienceDirect Topics
网页Prenylation is a complex, sequence-dependent C-terminal modification of proteins most commonly coded for by the last four (but sometimes alternatively three) amino acids, most frequently as a CaaX motif [26–32]. The prenyl group is attached through a thioether linkage to a Cys (C of CaaX) four residues from the C-terminus.
Protein Prenylation: Enzymes, Therapeutics, and Biotechnology ...
网页2015年1月1日 · Protein prenylation is a ubiquitous covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It is essential for the proper cellular activity of numerous proteins, including Ras family GTPases and heterotrimeric G-proteins.
Protein Prenyltransferases and Their Inhibitors: Structural and ...
网页2022年5月12日 · Protein prenylation is a post-translational modification controlling the localization, activity, and protein–protein interactions of small GTPases, including the Ras superfamily. This covalent attachment of either a farnesyl (15 carbon) or a geranylgeranyl (20 carbon) isoprenoid group is catalyzed by four prenyltransferases, namely ...
Protein Prenylation: Enzymes, Therapeutics, and Biotechnology ...
网页2014年11月17日 · Protein prenylation is a ubiquitous covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It is essential for the proper cellular activity of numerous proteins, including Ras family GTPases and heterotrimeric G-proteins.
Protein Prenylation - SpringerLink
网页Protein prenylation is a post‐translational modification involving the attachment of a 15 or 20 carbon isoprenoid group to a protein. In each case the prenyl group is attached to a specific cysteine amino acid residue near the C‐terminus of the protein via …
Prenylated Proteins: Structural Diversity and Functions
网页2022年11月4日 · Prenylation of proteins include the farnesylation and geranylgeranylation, with the farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP) as substrates respectively . These hydrophobic prenyl groups anchor the proteins to the cellular membranes and can trigger several cells signaling pathways.