Pyridine: the scaffolds with significant clinical diversity
网页Topical isolation of the structurally-modified natural products diploclinide and nakinadine contain pyridine moiety. Atazanavir (Rey-ataz) and imatinib mesylate (Gleevec) are medicinally-active pyridine derivatives. These drugs are useful against human immune deficiency virus (HIV) and chronic myelogenous leukemia.
Recent Advances in Pyridine Scaffold: Focus on Chemistry, …
网页2023年5月18日 · The most important pyridine-based therapeutic drugs are isoniazid (brand name: Nydrazid; an antibiotic for tuberculosis), esomeprazole (brand name: Nexium), lansoprazole (brand name: Takepron), montelukast (brand name: Singulair), pioglitazone (brand name: Actos), etc. (Figure 1).
The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug …
网页2021年10月13日 · In the US FDA database, there are 95 approved pharmaceuticals that stem from pyridine or dihydropyridine, including isoniazid and ethionamide (tuberculosis), delavirdine (HIV/AIDS), abiraterone acetate (prostate cancer), tacrine (Alzheimer’s), ciclopirox (ringworm and athlete’s foot), crizotinib (cancer), nifedipine (Raynaud’s syndrome and …
Pyridine: the scaffolds with significant clinical diversity
网页2022年5月20日 · The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an important position as a precious source of clinically useful agents in the field of medicinal chemistry research. This privileged scaffold has been consistently incorporated in a diverse range of drug candidates approved by the FDA.
Novel pyridine and pyrimidine derivatives as promising anticancer ...
网页2022年6月1日 · Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having plethora of applications in anticancer drug development. These synthetic sources serve as the potent class of compounds in treatment of breast cancer, myeloid leukemia, pancreatic cancer, liver cancer and idiopathic respiratory fibrosis etc.
Pyridine Derivatives as Biologically Active Precursors; Organics …
网页2021年4月1日 · Pyridine, an important heterocyclic compound is part of various medicines to combat different human ailments. Omeprazole, Netupitant, Abemaciclib, Ivosidenib, Lorlatinib and Apalutamide have been approved by FDA, several compounds are in the process of clinical trials.
Synthesis of substituted pyridines with diverse functional groups …
网页2023年6月7日 · Pyridine is a simple six-membered heterocyclic scaffold found in various natural products, drug molecules, vitamins, and materials (Fig. 1a) 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12. The...
Pyridines, Dihydropyridines and Piperidines: An Outline on …
网页2022年4月24日 · 1.1.1 Introduction. Pyridine is a six-membered cyclic molecule that belongs to a significant class of nitrogen heterocycles found in many active pharmaceuticals, natural products, and functional materials. It is a planar molecule that follows Huckel’s criteria for aromaticity.
Pyridines - DrugBank Online
网页An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis (DVT) leading to pulmonary embolism (PE), including in patients after a hip or knee replacement surgery. Mepyramine.
Role of pyridines as enzyme inhibitors in medicinal chemistry
网页2023年1月1日 · Many of the pyridine drugs are enzyme inhibitors such as indinavir, milrinone, and nevirapine. Promising results with the pyridinyl moiety open up the door for the development of a new generation of inhibitors. This chapter aims to review the progress in enzyme inhibition by pyridine-heterocyclic systems.