Tamoxifen-resistant breast cancer cells are resistant to DNA …
网页2018年4月23日 · In this study, we show that tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1, which is caused by activated PI3K/AKT...
Proteomic analysis of acquired tamoxifen resistance in MCF-7 …
网页2012年3月14日 · The forced overexpression of S100P in the tamoxifen sensitive MCF-7 cell line increased its resistance to tamoxifen significantly (Figure 8B), confirming the role of S100P in acquired tamoxifen resistance. Our results suggest that, as the ER-regulated proliferation pathway was severely suppressed after …
Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells
网页Here, we show that the eIF4F translation pathway was hyperactive in tamoxifen-resistant (TamR) MCF-7L breast cancer cells. While overexpression of eIF4E was not sufficient to confer resistance to tamoxifen in MCF-7L cells, its function was necessary to maintain resistance in TamR cells.
2-methoxyestradiol sensitizes tamoxifen-resistant MCF-7 breast …
网页2024年8月21日 · Our study aimed to explore the potential of combining the 2-ME and tamoxifen (TAM) on sensitization of TAM-resistant cells using LCC2 the TAM-resistant cells as a model and comparing the results to the sensitive cells MCF-7. Sulphorhodamine-B (SRB) assay is used to examine the 2-ME chemo-sensitizing impact on the cytotoxicity of TAM on LCC2 cells.
Induced Tamoxifen Resistance is Mediated by Increased
网页2019年10月2日 · Tamoxifen-resistant MCF-7-TAM (red) cells and the tamoxifen-resistant MCF-7-TAM with over-expressed E-cadherin (blue) were treated with indicated concentrations of tamoxifen for 72 hours (A...
Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells …
网页2017年6月2日 · Here, we show that the eIF4F translation pathway was hyperactive in tamoxifen-resistant (TamR) MCF-7L breast cancer cells. While overexpression of eIF4E was not sufficient to confer resistance to tamoxifen in MCF-7L cells, its function was necessary to maintain resistance in TamR cells.
Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells
网页2017年6月2日 · Here, we show that the eIF4F translation pathway was hyperactive in tamoxifen-resistant (TamR) MCF-7L breast cancer cells. While overexpression of eIF4E was not sufficient to confer resistance to tamoxifen in MCF-7L cells, its function was necessary to maintain resistance in TamR cells.
Overexpression of COL11A1 confers tamoxifen resistance in
网页2024年5月28日 · To investigate the role of COL11A1 in tamoxifen resistance, we stably transfected tamoxifen-sensitive, ER+ breast cancer MCF-7 and T47D cells with COL11A1 plasmid, and confirmed a notable...
EZH2 knockdown in tamoxifen-resistant MCF-7 cells unravels …
网页Inhibition of EZH2 has proven to reverse the tamoxifen resistance back to the sensitive state in breast cancer. However, the molecular players involved in EZH2-mediated effects on tamoxifen-resistant MCF-7 cells are unknown. This study was conducted to understand the global change in proteome profile of tamoxifen-resistant MCF-7 breast cancer ...
MCF-7 Cells—Changing the Course of Breast Cancer Research and …
网页2015年3月31日 · Many groups have also developed MCF-7 cells that are resistant to the antiestrogen tamoxifen. Studies of these lines have shown alterations in growth factor signaling, epithelial to mesenchymal transition, autophagy, and other critical pathways ( 19).