WAVE complex regulation by force | Nature Cell Biology
网页2021年11月4日 · The WAVE regulatory complex is well known as an orchestrator of actin dynamics at the leading edge of migrating cells. A recent study shows how mechanical effects can regulate the WAVE...
Structures reveal a key mechanism of WAVE regulatory complex …
网页2022年9月16日 · The Rho-family GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization in many essential processes. Rac1 binds to WRC at two distinct sites...
Orchestration of synaptic functions by WAVE regulatory complex …
网页2023年6月1日 · The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in...
WAVE regulatory complex: Current Biology - Cell Press
网页2021年5月24日 · Among the WASP-family proteins, WAVE (WASP family Verprolin homolog — also known as SCAR for suppressor of cAMP receptor) is uniquely regulated through its constitutive incorporation into a large protein assembly of ∼400 kDa, known as the WAVE regulatory complex (WRC).
The WASP and WAVE family proteins - PMC - National Center for ...
网页2009年10月6日 · The Wiskott-Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein (WAVE) family proteins are fundamental actin-cytoskeleton reorganizers found throughout the eukaryotes.
Actin Waves: Origin of Cell Polarization and Migration?
网页Actins. Actin filaments and associated proteins undergo wave-like movement in various cell types. Recent studies with cutting-edge analyses, including live-cell imaging, biophysical monitoring and manipulation, and mathematical modeling, have highlighted roles of 'actin waves' in cellular protrusion, polari ….
An Actin-Based Wave Generator Organizes Cell Motility
网页2007年8月14日 · Depolymerization of actin with latrunculin increases wave lifetime 20-fold to 488 ± 13.6 s and increases the intensity of membrane-associated Hem-1 by more than an order of magnitude, suggesting that actin polymer drives Hem-1 off of the membrane (Figure 4B and 4C, Videos S15 and S16).
From actin waves to mechanism and back: How theory aids ... - eLife
网页2023年7月10日 · Actin waves are micron-scale cytoskeletal regions of increased filamentous actin density that propagate in a wave-like fashion in the actin cortex (Carlsson, 2010). They are typically also enriched in other actin-related proteins and regulatory components and may be associated with localized signaling processes at …
Actin Waves: Origin of Cell Polarization and Migration? - Cell …
网页2017年3月7日 · Actin waves emerge and propagate spontaneously within cells. However, recent studies reveal that waves are also regulated by cell signaling, providing clues to understanding the mechanisms of wave generation. PIP 3, Rac1, Arp2/3, cofilin, and shootin1 accumulate in axonal actin waves [8,9,25].
WAVE, a novel WASP‐family protein involved in actin reorganization ...
网页1998年12月1日 · Ectopically expressed WAVE induces the formation of actin filament clusters that overlap with the expressed WAVE itself. In this actin clustering, profilin, a monomeric actin‐binding protein that has been suggested to be involved in actin polymerization, was shown to be essential.
- 某些结果已被删除